Synthesis and anodic electrochemistry of cymanquine
and related complexes
Ernazar Kamal
Department of Chemistry, School of Science and Technology, Nazarbayev University, Astana,
Kazakhstan
Email: [email protected]
Abstract
Contemporary bioorganometallic chemistry is on the path of study of biologically active, hybrid
molecules that contain organometallic parts. There is already variety naturally synthesized
biorganometallic complexes, such as Vitamin B-12 or methyl coenzyme M reductase, which
are essential for many organisms for survival. To go further, many chemists nowadays trying
to synthesize bioactive molecules, which can be used in disease treatments or can mimic the
naturally occurring compounds. For that reason, the study was focusing on the synthesis of three
compounds in which a 4-aminochloroquinoline moiety is covalently linked to a
cyclopentadienyl manganese tricarbonyl group. The anodic electrochemistry of these
compounds was investigated in dichloromethane, using [NBu 4 ][B(C 6 F 5 ) 4 ] as a supporting
electrolyte. These compounds undergo oxidation at considerably high positive potentials and
are highly irreversible, being located at their amine groups rather than the organometallic
compounds. Moreover, one of these compounds, termed “Cymanquine”, exhibits enhanced
bioactivity in the treatment of melanoma than the anti-cancer drug, chloroquine 2 .
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