Wellington Today Wellington Today 2018 en | Page 15

2018 WELLINGTON SCHOOL LIFE ACADEMIC EXCELLENCE fact, epigenetic changes happen to you every day, all of the time. For example, if you are drinking a beer, your liver cells will ‘switch on’ the gene to make the enzyme (which is made of protein) to break down alcohol. Epigenetic changes like this are constantly altering how your DNA is utilised on a day-to-day basis, resulting in further variation. The answer finally came in the form of a process called gene splicing. Insects cannot splice genes. Put simply, a fruit fly has 20,000 genes and can therefore make 20,000 types of proteins. Humans, however, have 25,000 genes which can be spliced into various forms, which means that each of these 25,000 genes can be made into over twenty different forms, which in turn creates enough genetic variation to stop you looking anything like a fly! So how is it that each cell in the human body contains identical DNA? Surely, a liver cell is a very different thing compared to a brain cell? Yes, they are different, but both contain identical DNA sequences and thus they share identical genes. The difference between them is whether these genes can be ‘switched on or off’. The discovery of this ‘on or off’ state of genes is relatively new, and is known as epigenetic control. Epigenetics is the new paradigm shift in the field of genetics as it concerns the control of DNA and thus the control of genes themselves. Different cells have different genes ‘switched on or off’ and this results in different proteins being formed and thus producing variation. In To the surprise of the biological community, it was recently discovered that these changes can also be passed on to offspring through the alteration of the epigenetics in the DNA of sperm cells. A research study carried out in Switzerland has shown that inducing a heart attack in a mouse confers a resistance to heart attacks in subsequent generations due to changes in epigenetics of the sperm, which are then passed on after fertilisation. Indeed, your parents are not only responsible for the genes you inherit; they are also responsible for determining how those very genes behave as well! This even applies in the case of identical twins: the twins may share identical genes but after fertilisation each embryo undergoes epigenetic changes, which makes each child subtly but tangibly unique. So where does this leave us? We are still all related by DNA but it is the tiny changes in DNA sequence and decoding that cause differences in our physical appearance and biological makeup. We have a tendency as a species to spot differences – hair colour, eye colour, skin colour, etc, yet we forget how similar we are. We all have a heart with four chambers connected by a huge network of blood vessels. We all have the same basic biological needs. Perhaps it would be better if we were to reflect on the similarities that we all share, rather than the 0.5% variation in our genes. Nevertheless, it is fascinating to think that these tiny but crucial little differences produced the likes of Einstein, Da Vinci, Mandela, Beethoven and Lionel Messi. CELEBRATING GRADUATION SUCCESS AT WELLINGTON COLLEGE INTERNATIONAL TIANJIN Our annual Graduation ceremony took place on the 26th April 2017. We were delighted to welcome our distinguished guest Clare Pearson, Chair of the British Chamber of Commerce for China, who delivered a truly inspirational speech to our pupils. The evening was a great success; more than half of our Year 13 pupils performed or spoke on stage, some of whom were performing here at Wellington for the first time. Our graduates are going on to study at some of the most prestigious universities across the world, including Parsons School of Design in New York, the Universities of Toronto, NYU, Warwick, Edinburgh, Glasgow, Royal Holloway, the London Schoo l of Economics (LSE), Central Saint Martins, School of Art, as well as Bond and Monash Universities in Australia. We are immensely proud of their achievements. These young Wellingtonians leave us with the values instilled in them during their time here with us; we know that they are well equipped to progress on to the next stage in their lives and we wish them all the very best as they leave us, safe in the knowledge that they will forever be part of the global Wellington family. Our vision at Wellington College is to educate pupils to thrive in an ever-changing global society, and there are few occasions more gratifying than seeing passions being pursued at some of 27 the world’s finest and most progressive universities and higher education institutions. Our pupils have worked tremendously hard to achieve the offers below and we are very proud of them indeed. Congratulations need to be extended in a variety of directions. The invaluable support of a truly professional and motivated teaching team who have guided pupils through a myriad of selection and opportunity in finding the right courses and locations for them; the relentless and ongoing support of parents in communicating proactively with representatives of the College and most importantly, for allowing the College to bring out the very best in their children academically. Finally, our huge congratulations go to our pupils. In persevering to achieve their set goals they have learned lessons in humility, independence in learning and research, vital soft skills in communication, teamwork and the importance in trusting others. Their achievements are even more incredible, considering that some of them are non-native English speakers and they are competing with students from all over the world. Our vision states ‘We aspire to create a caring international community that develops well-rounded individuals with strong values and the skills to thrive in an ever-changing global society.’ These are the pupils that we are sending out into the wider world. 28