Vet360 Vol 03 Issue 03 June 2016 | Page 32

CANINE MEDICINE mucocoeles were successfully managed with medical therapy.1 One dog was treated with SAMe, omega-3 fatty acids, famotidine, ursodiol, and levothyroxine. The second dog received ursodiol, fenbendazole, and levothyroxine and was fed a hypo-allergenic diet. Levothyroxine was used to treat hypothyroidism, and fenbendazole was used for prophylactic gastrointestinal parasite therapy. These patients showed complete ultrasonographic resolution of the mucocele after two and three months.1 Surgical intervention should be recommended in all dogs that fail to improve with medical therapy, including those with unresolved clinical signs, worsening laboratory findings, and progressing ultrasonographic abnormalities. Summary Gallbladder mucocoeles are being diagnosed with increasing frequency in dogs, but their true incidence remains uncertain. The underlying cause of this condition is still controversial, but there is a strong association with mucous gland hyperplasia within the gallbladder epithelium. While surgical management has been the historic treatment of choice, recent casebased evidence suggests that some patients may respond to medical management. References 1. Walter R, Dunn ME, d'Anjou MA, et al. Nonsurgical resolution of gallbladder mucocele in two dogs. J Am Vet Med Assoc 2008;232(11):1688-1693. 2. Samuelson DA. Textbook of veterinary histology. 1st ed. Philadelphia, Pa: WB Saunders Co, 2006;367-369. 3. Guyton AC, Hall JE. Textbook of medical physiology. 11th ed. Philadelphia, Pa: Elsevier Inc, 2006;802-804. 4. Ko CW, Sekijima JH, Lee SP. Biliary sludge. Ann Intern Med 1999;130(4):301-311. 5. Brömel C, Barthez PY, Léveillé R, et al. Prevalence of gallbladder sludge in dogs as assessed by ultrasonography. Vet Radiol Ultrasound 1998;39(3):206-210. 6. Tsurumi K, Onda M. A fluorescence histochemical study for the motility of the gallbladder. Gastroenterol Jpn 1979;14(2):147-154. 7. Guo YS, Singh P, Gomez G, et al. Contractile response of canine gallbladder and sphincter of Oddi to substance P and related peptides in vitro. Dig Dis Sci 1989;34(6):812-817. 8. Milenov K, Vassileva M, Marinova D, et al. Effect of neurotensin on the canine gallbladder motility: in vivo and in vitro experiments. Neuropeptides 1993;25(4):233239. 9. Strah KM, Melendez RL, Pappas TN, et al. Interactions of vasoactive intestinal polypeptide and cholecystokinin octapeptide on the control of gallbladder contraction. Surgery 1986;99(4):469-473. 10. Harkema JR, Mason MJ, Kusewitt DF, et al. Cholecystotomy as treatment for obstructive jaundice in a dog. J Am Vet Med Assoc 1982;181(8):815-816. 11. Neer TM. A review of disorders of the gallbladder and extrahepatic biliary tract in the dog and cat. J Vet Intern Med