Vet360 Vol 4 Issue 3 June 2017 Vet360 - Page 7

ADVERTORIAL Efficacy of oral afoxolaner for the treatment of canine generalised demodicosis Frédéric Beugnet 1 ,*, Lénaïg Halos 1 , Diane Larsen 1 , and Christa de Vos 2 1 Merial S.A.S., 29 avenue Tony Garnier, 69007 Lyon, France 2 Clinvet International (Pty) Ltd, PO Box 11186, 9321 Universitas, South Africa Received 25 January 2016, Accepted 10 March 2016, Published online 24 March 2016 Parasite 2016, 23, 14 . Published by EDP Sciences, 2016 DOI: 10.1051/parasite/2016014 Abstract – The efficacy of oral treatment with a chew- able tablet containing afoxolaner 2.27% w/w (Nex- Gard, Merial) administered orally was assessed in eight dogs diagnosed with generalised demodicosis an d compared with efficacy in eight dogs under treatment with a topical combination of imidacloprid/moxidec- tin (Advocate, Bayer). Afoxolaner was administered at the recommended dose (at least 2.5 mg/kg) on Days 0, 14, 28 and 56. The topical combination of imida- cloprid/moxidectin was given at the same intervals at the recommended concentration. Clinical exam- inations and deep skin scrapings were performed every month in order to evaluate the effect on mite numbers and the resolution of clinical signs. The per- centage reductions of mite counts were 99.2%, 99.9% and 100% on Days 28, 56 and 84, respectively, in the afoxolaner-treated group, compared to 89.8%, 85.2% and 86.6% on Days 28, 56 and 84 in the imidacloprid/ moxidectin-treated group. Skin condition of the dogs also improved significantly from Day 28 to Day 84 in the afoxolaner-treated group. Mite reductions were significantly higher on Days 28, 56 and 84 in the afox- olaner-treated group compared to the imidacloprid/ moxidectin-treated group. The results of this study demonstrated that afoxolaner, given orally, was effective in treating dogs with gener- alised demodicosis within a two-month period. Efficacy of afoxolaner in a clinical field study in dogs naturally infested with Sarcoptes scabiei Frédéric Beugnet ,*, Christa de Vos , Julian Liebenberg 2 , Lénaïg Halos 1 , Diane Larsen 1 ,and Josephus Fourie 2 1 2 1 Merial S.A.S., 29 avenue Tony Garnier, 69630 Lyon, France 2 Clinvet International (Pty) Ltd, PO Box 11186, 9321 Universitas, South Africa Received 31 March 2016, Accepted 5 June 2016, Published online 17 June 2016 Abstract – The acaricidal efficacy of afoxolaner (NexGard_, Merial) was evaluated against Sarcoptes scabiei var.canis in a field efficacy study, when administered orally at a mini- mum dose of 2.5 mg/kg to dogs naturally infested with the mites. Twenty mixed-breed dogs of either sex (6 males and 14 females), aged over 6 months and weighing 4–18 kg, were studied in this randomised controlled field efficacy tri- al. Dogs, naturally infested with Sarcoptes scabiei var. canis confirmed by skin scrapings collected prior to allocation, were randomly divided into two equal groups. Dogs in Group 1 were not treated. Dogs in Group 2 were treated on Days 0 and 28. On Days 0 (pre-treatment), 28 (pre-treatment) and 56, five skin scrapings of similar size were taken from different sites with lesions suggestive of sarcoptic mange. The extent of lesions was also recorded on Days 0, 28 and 56, and photographs were taken. Dogs treated orally with afoxolaner had significantly (p < 0.001) lower mite counts than untreated control animals at Days 28 and 56 with no mites recovered from treated dogs at these times (100% efficacy based on mite counts). In addition, dogs treated with NexGard had significantly (p < 0.05) better lesion resolution at Day 56 than Day 0; no treated dog showed pruritus compared to 7/10 dogs in the control group, 1/9 treated dogs had crusts compared to 5/10 controls and 8/9 dogs recovered 90% of hairs on le- sions compared to 0/10 control dogs. Shift to training and research solutions made to measure. Partner with Enterprises University of Pretoria to make the shift towards integrated training, research and advisory services by collaborating with world-class experts to create all-inclusive corporate solutions. TRAINING SOLUTIONS RESEARCH SOLUTIONS Training programmes and short courses • Applied research Online and CPD courses • Advisory services Customised courses for corporate training Earn a certificate from the University of Pretoria • Specialised services • Direct access to experts from the University of Pretoria You have a plan. We have a way to make it happen. Ask us how. SMS the keyword ENTERPRISES followed by VET360 your name and email to 43366 to receive more information about our full offering. Shifting knowledge to insight +27 (0)12 434 2500 | enterprises.up.ac.za Parasite 2016, 23, 26, DOI: 10.1051/parasite/2016026 RESEARCH Issue 03 | JUNE 2017 | 7