Vet360 Vol 3 Issue 04 August 2016 - Page 26

GASTROENTEROLOGY Wheaten Terrier’s, Irish Setters, with their individual nuances. Monitoring Response to Therapy Follow up endoscopy and histopathology: Although repeated IBD activity index scores are the most common way patients are monitored repeat endoscopic and histopathology studies have been regularly performed in academic/research studies. Improving IBD index scores is usually associated with an improved intestinal mucosal appearance endoscopically and improved intestinal mucosal integrity and, if specialised organism detecting techniques are used, with a decrease in mucosal adhesion and invasion of potential pathogens; but the actual lamina propria inflammatory cell numbers may not be decreased in these repeat biopsies. One explanation for this may be decreased post event apoptosis of the resident lymphocyte populations another may be continued unresolved underlying perturbations. Selected references in text • • • • • • • Sauter, S.N. et al (2006) Effects of probiotic bacteria in dogs with food responsive diarrhoea treated with an elimination diet. J Anim Physiol Anim Nutr 90:269–277 German, A.J., et al (2010) First-choice therapy for dogs presenting with diarrhoea in clinical practice. Vet Rec 21:810 Herstad, H.K. et al (2010) Effects of a probiotic intervention in acute canine gastroenteritis--a controlled clinical trial. J Small Anim Pract 51:34 Bybee, et al (2011) Effect of the probiotic Enterococcus faecium SF68 on presence of diarrhea in cats and dogs housed in an animal shelter. J Vet Intern Med 25:856 Dossin, O. et al (2011) Effect of Parvoviral Enteritis on Plasma Citrulline Concentration in Dogs. J Vet Intern Med 25: 215–221 Rath, H.C. (2003) The role of endogenous bacterial flora: bystander or the necessary prerequisite? Eur J Gastroenterol Hepatol 15:615–620 Rossi, G. et al (2014) Comparison of Microbiological, Histological, and Immunomodulatory Parameters in Response to Treatment with Either Combination Therapy with Prednisone and Metronidazole or Probiotic VSL#3 Strains in Dogs with Idiopathic Inflammatory Bowel Disease. PLoS ONE 9:e94699. doi:10.1371/journal.pone.0094699 Remainder of references available on www.vet360. vet360 Issue 04 | AUGUST 2016 | 26 VET360 AUGUST 2016 working.indd 26 2016/07/25 11:04 PM