Vet360 Vet360 Vol 05 Issue 03 | Page 34

CPD Questions

Article - Gastrointestinal Therapy , Anti-emetics and Antacids
AC / 1935 / 18
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Question 1 : Which one of the phrases below regarding the vomiting mechanism is INCORRECT ? a . The CTZ relies on dopamine receptors . b . Vestibular nausea relies on histamine receptors . c . The VC is in the medulla within the blood brain barrier . d . GIT stimulation of vomiting is seratonergic e . The CTZ has a inhibitory effect on the VC
Question 2 : Which one of statements regarding omeprazole is CORRECT ? a . Omeprazole is active on the gastric side of the parietal cell . b . Omeprazole is proton pump activator . c . Omeprazole is not effective in cats . d . Omeprazole is most effective administered BID . e . Omeprazole has no evidence of efficacy in dogs .
Question 3 : Which one of the statements regarding anti-emetics listed below is INCORRECT ? a . Metoclopramide has mild prokinetic activity . b . Maropitant has demonstrated efficacy in cats . c . Maropitant relies on inhibition of substance P binding to NK receptors . d . Maropitant has mild prokinetic activity . e . Ondansetron blocks seratonergic transmission in the chemoreceptor trigger zone and vagal afferent nerves .
Question 4 : Which one of the components of the gastric mucousal defence systems listed below is INCORRECT ? a . pre-epithelial mucous-bicarbonate barrier b . the epithelial barrier and continuous cell renewal of epithelial cells c . continuous mucosal blood flow d . normal gastric through-flow and emptying e . generation of vasodilatory prostaglandins and nitric oxide
Question 5 : Which one of the statements listed below regarding gastric acid production is CORRECT ? a . Acid production is stimulated by the binding of gastrin to the proton-pump mechanism . b . Hydrogen molecules are secreted by proton pumps on the luminal surface of the parietal cells . c . Acetylcholine and histamine receptors are present on the luminal surface of the parietal cell . d . H2 blockers will also block other stimulatory factors for acid production . e . Decreased blood flow will decrease acid production .
Question 6 : Which one of the statements below regarding omperazole is CORRECT ? a . Omeprazole acts by reversibly binding to the proton pump . b . Proton pump inhibitors should be administered
30 – 60 minutes before feeding for optimal effect . c . Omeprazole takes approximately 7 days for
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Issue 03 | JULY 2018 | 34 optimal suppression of acid production . d . The efficacy of omeprazole decreases over time . e . Once daily administration of omeprazole is sufficient for clinical benefit .
Question 7 : Which one of the statements regarding chronic kidney disease ( CKD ) in cats is INCORRECT ? a . CKD is a common condition where antacids must be considered . b . Recent evidence suggests that gastric ulceration is not a feature of CKD in cats . c There is little evidence to justify the use of antacids prophylactically in cats with uraemia . d The use of sucralfate in cats with CKD had to be discontinued prematurely due to excessive vomiting and anorexia . e . There are less studies critically evaluating the efficacy of antacids in cats compared to dogs .
Question 8 : Which of the followings statements regarding medications affecting gastric mucousal blood supply is CORRECT ? a . Misoprostil is a natural PGE ( prostaglandin E ) b . PGE is vasodilatory and effective in the gastric mucousa . c . Sucralfate blocks the synthesis of vasodilatory prostaglandins . d . Misoprostol is valuable only in the treatment of
NSAID induced ulceration . e . Hypovolaemia and shock have no effect on gastric blood flow .
Question 9 : Which one of the statements below regarding the administration of maropitant is CORRECT ? a . A single daily dose of maropitant was more effective compared to a single dose of metoclopramide . b . Maropitant should be used with caution in patients with suspected GI obstruction . c . Maropitant has a 24-hour duration of effect in dogs and cats . d . The injectable dose of maropitant should be administered at least 1 hour prior to chemotherapy for optimal effect . e . The oral dose is higher due to decreased oral bioavailability and is absprbition is decreased with the presence of food .
Question 10 : Which one of the statements below regarding metoclopramide is most CORRECT ? a . Severe CNS signs are the most common side effect of metoclopramide . b . Metoclopramide mixed with 0.9 % saline is not light sensitive and remains stable for 48 hrs . c . Metoclopramide is a serotonin antagonist . d . Metoclopramide acts only centrally . e . Metoclopramide is useful for the treatment of oesophagitis as it is a strong prokinetic .