Vet360 Vet360 Vol 05 Issue 03 - Page 32

CPD ARTICLE Sucralfate also stimulates the synthesis of capillary blood flow-promoting prostaglandins potentiating the natural defence mechanisms of the gastrointestinal tract. Because sucralfate can also bind other oral drugs, medications should be given 1–2 hours prior to sucralfate administration, as absorption is minimal,. Toxicity is uncommon. Long-term use may lead to constipation because of its aluminium content. There is no evidence to support that simultaneous therapy with other antacids provides added benefit compared to therapy with either sucralfate or an antacid alone. However, conceptually the two differences mechanism of action would suggest that this practice may be beneficial. In cases suffering from oesophagitis it is important to note that only liquid solution is considered to be effective. Misoprostol Misoprostol is valuable in managing cases suffering from nonsteroidal anti-inflammatory induced gastric ulceration. This drug is a synthetic prostaglandin E-analogue that can be used prophylactically or as treatment in these cases. It has been shown to significantly reduce aspirin-induced gastrointestinal ulceration compared to a placebo 12 . This study led to the suggested dose of 3 µg/kg, q8h, PO. Where misoprostol was used to prevent ulceration in dogs with intervertebral disc disease which were given a single dose of dexamethasone at 2mg/kg followed by a tapering course of prednisolone (2 mg/kg to 0.5 mg/ kg over the course of 5–6 days), no effect was seen at a dose of 2 μg/kg, q8h PO 13 . The most common side effect is diarrhoea and the drug may also cause abortion. Clinical Application of Antacids Despite the recent advances in our understanding of antacids in dogs and cats there is very little information on the effect of these drugs in animals with spontaneous disease. Most of the studies to date have been performed in heal ѡ䁅́ѥͥ)ɥѕɥЁ݅ɐյȁѡ)ٕɅѥɕͥͥɕ)ՅєѼɽєձȁQɔٕ́)ɵѥѡͥͥЁѕɴ)͔ѥձɱɽѽյѽ́ )х̸Qɵѥ́Ёձ)Ѽɽ٥ȁե́ѥ́)ѡ͔х̸)յՑɕٕͥ)ɕѥݕɕͥձ)́ͽѡɅѥͥх́)ɽѕѥձɅѥ́Ʌѕ)Ѽٕѕɥ䁵̀9݅́ɽѽյ)ѽ́ɔ͕յ́Ѽɕ)ɕѕͽɑ́Ս́ѥձ̰)!ѕȵͽѕɽɥѥ̰)ͥͽѕɡх)ɽͽɕ͕͔ѕɽ)ٕ)%Ք́)U1d)Ѥѽ䁑՝̵ͽѕɽս)ձ̸%ѥх́ɔͼ͕)ѥ́Ս́ɥѥ̰ɕѥѥ̰ѥ)͕͔ɕ͕͔)Aɽѽյѽ́ɔ䁕啐)ѡɕѵЁ!ѕȵͽѕɽ)ɥѥ́єѱ٥ѼЁѡ́Ʌѥ)̸Qѡͥ́ɽѕѥձɅѥ)ѥ͕͔́ɱչѽЁݕ)͍ɥѕɅɔѡȁՑ́ɔͅѼ)ѕɵѡ䁽х́ȁѡ́ѥ)ɽѕѥ)ձɅѥ)ͽѕ)ݥѠ)ٽ͍ɥѽѥ͕́́)єɕѥѥ͕́́́Ѽѡɽ居ѥ)͔х́ѡ͔ѥ̸!ݕٕȰ)݅́ɕѕݥѠѡɅѥɽѽյ)ѽ́ɽՑ䁥յ)ݥѠєɕѥѥ̀Ёѡɔٔ)Ց́əɵٕѕɥ䁵Ѽ)ѡ́ɅѥAѥ́ՙɥɽͽѥ́)ͼЁɽхѡɅ) ɽ䁑͕͔́ѡȁѥ)ݡɔх́䁉ͥɕх)ɕ͕͔յ́́ͽѕݥѠ)ɝɥɥѥ̰ɽѕѥ)ɽѕѥձɅѥЁѡɔɔ)ɕ́مՅѥѡɥ͕ɕѥɽ)́ȁ́ݥѠɕ͕͔IЁ٥)՝́ѡЁɥձɅѥ́Ёɔ)ɽ䁑͕͔͕́́́́)յ́ݥѠɅɥѥ̀ԀQ́՝)ѡЁѡɔ́ѱ٥Ѽѥѡ͔х)ɽ居ѥ䁥́ݥѠɅɕЁՑ)مՅѥѡ͔ՍɅє́є)́ݥѠɽ䁑͕͔݅́չѼ)ɴ䁉Ёȁ͔́́ѡՑ)Ѽ͍ѥՕɕɕ䁑ՔѼፕͥٔ)ٽѥɕ᥄ɕ͕́хѡ)ɽݥѠɽ䁑͕͔؀)Ʌ䰁ѡɔɔ́Ց́ɥѥ䁕مՅѥ)ѡ䁽х́́ɕѼ́)Ё͕́́ٔͅɅѕ)ɴѡ̸͔͕)ٕ͔́х)Qѕٕ͔́ɽ)ɕͅЁɅѥ́́ٔ)ɝ䁉ɅѕɽѡЁ͍ɥ)յ̸ 䰁ɡ ɥմ)ѥɕ͕ɥͬхեɕ)յɕ͕ɥͬɅɕ́ɥɥ)ɔѡЁ䁑͍ɥͥ)̀܀)ɡ́ѡЁٕ͔)ɕѕͽѥݥѠɽѽյѽ)Ʌѥ́Ё́ЁȁѼ)̀Qͥ́ɽѽ