UAB Comprehensive Cancer Center Magazine - Spring 2016 - Page 9

research update center profile “If we can understand the early events of childhood H pylori infection, we will be better prepared to block the long-term effects of H pylori and reduce the number of gastric cancers worldwide.” Phillip Smith, M.D. UAB Comprehensive Cancer Center senior scientist that knowledge could then potentially be applied to among men than women,” Dr. Smith says. “If what adults to help diminish their chances of developing we have found so far is accurate, it suggests that one gastric cancers, Dr. Smith adds. “H pylori causes of the bacteria that accompanies H pylori infection in cancer, but the accompanying microbiota may have a women may be inducing a more potent T-regulatory profound impact on the host response to H pylori.” response that protects women from the consequences of prolonged H pylori infection, including cancer.” Next Steps Dr. Smith and his colleagues are now working with important problem to study because of its prevalence activity they have observed in humans and seeing and potentially devastating consequences throughout if the results are similar. They are also expanding the world,” he says. “The stomach provides a their research to examine the differences in H pylori window into the interaction between the microbiota infections in women as compared to men. They have and mucosal pathogen. The consequence of that found H pylori-infected women have a four-fold higher interaction is inflammation, and if we can understand incidence of a certain bacteria that has been shown to the early events of childhood H pylori infection, we induce T-regulatory cell responses in animals. will be better prepared to block the long-term effects including Chile, gastric cancer is much more common U A B optimistic about the future. “H pylori infection is an microbiota in animal models to replicate the H pylori “This is important because throughout the world, 14 C O M P R E H E N S I V E Mansoor Saleh, M.D. It’s a puzzle with many pieces, and Dr. Smith is C A N C E R C E N T E R of H pylori and reduce the number of gastric cancers worldwide.” CENTER PROFILE UAB Comprehensive Cancer Center Magazine salutes Mansoor Saleh, M.D., professor of medicine and By JOSH TILL senior scientist in the UAB Comprehensive Cancer Center. Dr. Saleh serves as medical director of the UAB Clinical Trials Administrative Office and the director of UAB’s Phase I Program. He received his medical degree from the University of Heidelberg in Germany and completed his internship and residency at the Henry Ford Hospital in Detroit, Michigan. Dr. Saleh and his wife Salmah have been married 35 years and have two children: Imran, a computer software product manager in Toronto, and Aleha, a pediatric oncology nurse at Children’s of Alabama. # K N O W U A B C C C • U A B . E D U / C A N C E R 15