The Mirror, December 2018 The Mirror, December 2018 | Page 14

IS HYPOPHOSPHATASIA (HPP)
IN YOUR PRACTICE?
99% of all patients with HPP
experience tooth loss (with the
root intact) before the age of 5 1
What is HPP?
A life-threatening genetic disorder 2
Caused by loss of function mutations in
the alkaline phosphatase gene ( ALPL ) 2
ALP enzyme deficiency disrupts
mineralization of bones and teeth, causing
numerous devastating consequences 2
1. Refer your patient to the local children’s hospital dental service or HPP
medical expert to ensure further assessment, diagnosis, and the
management of the patient
2. Schedule regular check-ups to monitor oral health, tooth loss, and
space maintenance
REFERENCES:
1. Whyte M, et al. Hypophosphatasia: Validation and expansion of the clinical nosology for children from 25 years experience with
173 pediatric patients. Bone . 2015;75:229-239.
2. Rockman-Greenberg C. Hypophosphotasia. Pediatr Endocrinol Rev . 2013;10:380-388.
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