Closing Thoughts
This concludes my examination of rheumatoid
arthritis through pathogenesis, the general anatomy
and physiology of the organs effected, and the
normal operations of microscopes as a means for
diagnosing RA.
Table 1
an identical antigen-binding site (called Fab or
fraction antigen-binding) on each arm of the Y. Each
arm is composed of light amino acid chain and a
heavy amino acid chain. The terms light and heavy
refer to the number of amino acids in each chain.
Because the heavy chain has more amino acids than
the light chain, it is longer and has a higher
molecular weight.”
“Both types of chains have a variable region (VL
and VH) and a constant region (CL and CH). The
variable regions contain the antigen-binding sites
and vary in amino acid sequence. The sequences
differ to allow immunoglobulins to recognize and
bind specifically to thousands of different antigens.
The constant region of the light chain (CL) is a
single section. Immunoglobulins that have identical
constant regions in their heavy chains (e.g., CH1,
CH2, and CH3) are of the same class.”
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