SALIVARY AND SERUM CORTISOL IN PATIENTS WITH PERIODONTAL DISEASE AND ORAL
LICHEN PLANUS
Positive correlation between stress and cortisol, stress
and clinical parameters, and cortisol levels and patients
with chronic periodontitis had been observed by Goyal
S et al. (30). At the same time Shah et all, observed a
positive correlation between psychological factors and
salivary cortisol levels in the OLP patients (34). Giardini
and co-workers, indicated an association between
OLP and anxiety, but salivary cortisol levels did not
differ between patients with OLP and control group
(33).
In our study, salivary and serum levels of cortisol were
statistically increased in OLP patients versus healthy
subjects. Until now there are no studies regarding
the serum level of cortisol at patients with OLP.
The World Health Organisation (WHO) classifies OLP
as a “potentially malignant disorder” and suggests
that OLP patients should be under close monitoring.
OLP patients present higher levels of anxiety,
depression because there are concern about the
malignant transformation of this oral diseases
(37).
Chronic inflammation leads to cortisol release
that counteracts inflammatory reactions and even
immunological functions, so this stress hormone
can be involved in the pathogenesis of OLP and
periodontal disease. In conclusion psychological
stress may influence the progression of these two
oral diseases.
Acknowledgements
This study was supported by the Sectorial Operational Programme Human Programme
Human Resources Development (SOP HRD), financed from the European Social Fund and by
the Romanian Government under the contract number POSDRU/6/1.5/S/S17.
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