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and thus crack induction points. One may hypothesize that under slight load the internal stress relaxation that happens within the material is enhanced and thus stress induction points may be reduced. In a clinical situation the crown material is not known to the orthodontist. The procedure used will work with any ceramic. Therefore, the proposed protocol is a safe approach. 5. Conclusion Based on the results of this in vitro study obtained with Cojet, Monobond Plus and Heliosit Orthodontic and considering the limitations of in vitro results one can conclude that • Under OL and TC, the highest bond strength was observed. • Load or TC alone yielded similar or lower shear bond strengths. • Sandblasting with CoJet and using Monobond Plus as primer is a good protocol for bonding to ZrO crowns in orthodontic therapy. Therefore, it is recommended for future in vitro tests of adhesives for orthodontic purposes to test under OL and TC. Author Contributions HSH: Performed experiment, wrote manuscript. NA: Performed experiment, proofread manuscript. CS: Data analysis, proofread manuscript. CD: Consulting of orthodontic aspects of experiment, proofreading manuscript. JFR: Idea, experimental design, proofread manuscript. Acknowledgments The authors declare no conflict of interest related to this study. There are no conflicts of interest and no financial interests to be disclosed. References 1. 2. 3. 4. 5. 6. 7. Studart AR, Filser F, Kocher P, Lüthy H, Gauckler LJ. Cyclic fatigue in water of veneer – framework composites for all-ceramic dental bridges. Dent Mater. 2007;23(2):177-185. doi: 10.1016/j. dental.2006.01.011. [Full text links] [PubMed] Google Scholar(139) Scopus(73) Al-Amleh B, Lyons K, Swain M. Clinical trials in zirconia. A systematic review. J Oral Rehabil. 2010;37(8):641-652. doi: 10.1111/j.1365-2842.2010.02094.x. [Full text links] [PubMed] Google Scholar(378) Scopus(227) Vult Von Steyern P, Carlson P, Nilner K. All-ceramic fixed partial dentures designed according to the DC-Zirkon technique. A 2-year clinical study. J Oral Rehabil. 2005;32(3):180-187. doi: 10.1111/j.1365-2842.2004.01437.x. [Full text links] [PubMed] Google Scholar(407) Bavbek NC, Roulet JF, Özcan M.