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[26] evaluated 127 questionnaires about autologous donation of blood in patients who underwent orthognathic surgery; 65 patients (51%) reported that autologous blood donation was decisive for the agreement to operate and that 12 patients (9%) would have refused the operation without the possibility of autologous blood donation. It should be recommended that the decision to offer the possibility of preoperative autologous blood donation should not be done as a gain-framed or loss-framed persuasive message. A loss-framed persuasive appeal emphasises the disadvantages of failing to comply with the communicator’s recommendation; in contrast, the gain-framed appeal will emphasise the advantages of compliance. Both are well-known techniques in patient communication [67]. Obviously, legal recommendations [66] and court rules in Germany [22] and in the United States [24] do not facilitate the information task towards the patient [26], because the patients need to be informed about the risks of homologous transfusion and the possibility of autologous blood transfusion as an alternative. Blau et al [49] reported that based on the perceived safety of reinfusion of autologous blood, the transfusion decision was made even before knowledge of the postoperative hemoglobin level. 5. Discussion and Conclusions Considering the risk factors for blood transfusion after orthognathic surgery, a great deal of attention has been focused in the past both on the relationship with the duration of the surgery and the blood loss during surgery and in the postoperative period. Blood loss and duration of surgery are only weakly related to each other. The most significant factor in deciding when to transfuse is one’s attitude towards transfusion and the related ‘trigger’ criterion for transfusion. Although the contemporary limit of 7 g/dL is a safe margin for healthy persons, the measurable increase in cardiac output needs to be observed. It is important to know that Hb drop could be overestimated due to hemodilution, which in return may influence the decision of blood transfusion [68]. The estimated blood loss might be a good guide, especially in cases that received large amounts of i.v. fluids. According to Al-Sebaei et al [69], blood loss does not consistently increase over time. The majority of intra-operative blood loss is expected to occur in the beginning of the procedure during the performance of the osteotomies [69]. On the other hand, it has been shown that predonation of autologous blood both increases the necessity and the opportunity to use it. Nevertheless, any blood transfusion is graded as a grade II complication in the Clavien-Dindo complication classification system. Minimising perioperative blood loss seems to be a multidisciplinary task in which both the anesthesiologist and the surgeon share a common responsibility. The timely adaptation of legal guidelines to adopting a nontransfusion default position when there is no evidence for potential benefit is the wise approach. and prepared the protocol. CP, JOA and IL were involved in the analysis of data and the writing of the manuscript. All authors read and approved the final manuscript. Acknowledgment Not applicable. The study was self-funded. There are no conflicts of interest and no financial interests to be disclosed. References 1. 2. 3. 4. 5. 6. 7. 8. 9. 10. 11. 12. 13. 14. 15. Author contributions CP was the principle investigator who initiated, designed Stomatology Edu Journal 16. Posnick JC, Rabinovich A, Richardson DT. 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