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operator differences: for instance, both White et al. [19] and El-Zanaty et al. [20] assessed only intra-examiner bias. Indeed, two or three different operators were involved in other studies, but only intra-operator variability was reported [6]. Similarly, Wiranto et al. [8] assessed the variability from three different operators, but did not report the actual inter-operator data, quoting a previous investigation. The excellent reproducibility of the three different measurement techniques is in line with the current literature reports. For instance, De Luca Canto et al. [2] made an extensive review to study the validity of measurements obtained from digital dental models produced from laser scanning against those directly made on the original physical dental models. The authors concluded that the current scientific evidence supports the validity of digital measurements. White et al. [19] tested the accuracy of the digital reproductions of dental models made by using CBCT scans, and foun d satisfactory values for intra-arch measurements but inaccurate inter-arch relationships. El-Zanaty et al. [20] compared linear distances obtained on plaster casts and from CT head scans; the two techniques had excellent agreement. More recent studies reported that both intraoral scanning and CBCT scanning of alginate impressions of the dental arches gave valid, reliable, and reproducible dental measurements for diagnostic purposes. Wiranto et al. [8] compared traditional plaster scans, scans obtained from intraoral scans, and CBCT scans of alginate impressions, and found that the digital reproduction of dental arches can be usefully employed for diagnostic purposes. In the current study, the worst coefficients of reproducibility were found for CBCT measurements, while the best were those obtained for plaster casts. For CBCT, similar data were reported by Kim et al. [4, 5]. Literature is not in agreement about the technique with the best reproducibility: both digital models [4, 5, 7], and plaster models [16] had the best scores in different studies. Overall, only three mesiodistal crown diameters had differences larger than 0.5 mm, which is considered the threshold for clinical acceptability [7, 18]. This corresponds to 8% of the analysed dental distances (3 out of 12 distances x 3 techniques values), a value larger than that reported by Tarazona-Álvarez et al. [6] who found only 5% of significant differences when comparing 20 linear distances obtained directly on dried mandibles and on their CBCT scans. Additionally, the current results well confirm that measurements involving the premolars are more variable than the other ones [4]. In general, the overestimation of calliper measurements vs. digital casts data is in line with the literature reports [18], while the comparison with CBCT data is more scattered. For instance, on dry mandibles, most of CBCT measurements were significantly smaller than those obtained by using the calliper [6]. 5. Conclusion In conclusion, measurements on digital dental models and CBCT reconstructions of the dental arches seem clinically reliable as direct measurements performed on dental plaster casts. Inter- and intra-operator reliability Stomatology Edu Journal Table 3. P values from Kruskal-Wallis test. Central First First First First Canine incisor premolar molar premolar molar Hemiarch Mesiodistal Vestibulopalatal Left maxillary 0.09 0.93 0.002* 0.93 0.18 0.47 Right mandibular 0.05 0.55 0.86 0.36 0.93 0.44 *Significant difference p < 0.01. For significant values, post hoc Wilcoxon tests: Calliper – CBCT: p = 0.002; Digital - CBCT: p = 0.03. were acceptable, while more care may be needed for CBCT measurements, as also underlined by previous studies [3, 4]. The results are promising, nevertheless further evaluations on a larger sample are advised. Author Contributions LP: design of the study, data collection and interpretation, drafting the MS, final approval of the MS; MC: design of the study, data elaboration, drafting the MS, final approval of the MS; SG: data collection, critical review of the MS, final approval of the MS; FMER: data collection and elaboration, critical review of the MS, final approval of the MS; GMT: design of the study, data elaboration and interpretation, critical review of the MS, final approval of the MS; VP: design of the study, data collection, drafting the MS, final approval of the MS; CS: design of the study, data interpretation, critical review of the MS, final approval of the MS. ARE DENTAL MEASUREMENTS TAKEN ON PLASTER CASTS COMPARABLE TO THOSE TAKEN FROM CBCT IMAGES AND LASER SCANNED SURFACES? Acknowledgments Not applicable. The study was self-funded. There are no conflicts of interest and no financial interests to be disclosed. References 1. 2. 3. 4. 5. 6. 7. Codari M, Pucciarelli V, Pisoni L, et al. Laser scanner compared with stereophotogrammetry for measurements of area on nasal plaster casts. Br J Oral Maxillofac Surg. 2015;53(8):769-770. doi: 10.1016/j.bjoms.2015.05.007. [Full text links] [PubMed] Google Scholar(4) Scopus(1) De Luca Canto G, Pachêco-Pereira C, Lagravere MO, et al. Intra- arch dimensional measurement validity of laser-scanned digital dental models compared with the original plaster models: a systematic review. Orthod Craniofac Res. 2015;18(2):65-76. doi: 10.1111/ocr.12068. [Full text links] [PubMed] Google Scholar(13) Scopus(4) Kau CH, Littlefield J, Rainy N, et al. Evaluation of CBCT digital models and traditional models using the Little’s Index. Angle Orthod. 2010;80(3):435-439. doi: 10.2319/083109-491.1. [Full text links] [PubMed] Google Scholar(78) Scopus(41) Kim J, Heo G, Lagravère MO. Accuracy of laser-scanned models compared to plaster models and cone-beam computed tomography. 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