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worked for the White House Office of National Drug Control explains that the impact of U.S. regulations has increased of drug flow from neighboring countries saying, "We've just created incentives for non-US producers to make more." 4 Gary Hill, a Drug Enforcement Administration assistant special agent in charge of the San Diego area reports similar findings. Hill describes the process by which the methamphetamine trade has evolved. He reports a recent shift of methamphetamine manufacturing to Mexico, Hill estimates that, “About 90 percent of meth now comes from outside of the US.” 4 The drugs are then stashed in large California metropolitan areas such as Los Angeles and San Diego counties, before being distributed across the country. The Mexican Drug Cartel influence has undoubtedly changed the landscape of drug presence in the United States. 1.1. Background Conventional wisdom would lead one to believe that the January 2016 re-capture of infamous drug lord Joaquín “El Chapo” Guzmán would disrupt the cartel’s operations. However, research conducted by the U.S. Customs and Border Protection found that the arrests or death of key Drug Trafficking Organization (DTO) leadership shows no discernable impact on overall drug flow in the United States. The research report explains that DTO operations have created a built in redundancy, personnel, and protocol to mitigate the impact of the removal of any one person. 5 It is clear that the regulatory measures have done little to address the issue of methamphetamine abuse in the United States. Instead, preventative measures may be more effective than punitive responses. Discussing how to deal with the methamphetamine problem in the U.S., Carnevale stresses the need for a comprehensive approach to combat the issue stating, "We need to focus heavily on prevention and education efforts to teach people about long-term effects. Meth use needs to be brought back into the national dialogue." 4 2. Prevalence On a global scale, methamphetamine use trends have continued to climb in the past several years. According to the United Nations Office on Drugs and Crime, there are an estimated 25 million abusers of methamphetamines worldwide. These figures exceed both cocaine and heroin, which were estimated to be 14 million and 11 million respectively. 6 A possible explanation for the increase prevalence of methamphetamine is the ability to produce the drug with commonly accessible synthetic chemicals as compared to the natural derivatives of heroin and cocaine. Nationwide estimates show that number of persons aged 12 or older who were current nonmedical users of stimulants was 1.4 million, which was higher than estimates in 2012 (1.2 million) and 2011 (970,000). Methamphetamine abuse mirrored the upward trend of stimulant use for persons aged 12 or older. In 2013, estimates of methamphetamine were 595,000, which were higher then estimates for 2012 (440,000) and 2011 (439,00). 3 Furthermore, the number of methamphetamine initiates (first time Stomatology Edu Journal users) among persons aged 12 or older was 133,000 in 2012, which was similar to estimates in 2011, and up from 2010 (107,000). 6 3. Demographics A variety of factors contribute to methamphetamines and stimulants use across multiple demographics. A 2004 study in New York’s club scene found that significantly higher proportion of Caucasian individuals reported lifetime use of methamphetamine compared to African American and Hispanic individuals. 7 In a second study, several of the same authors found differences in other illicit drug use between ethnic groups in New York City, such as higher rates of injected drug and ecstasy use amongst Caucasians; along with increased rates of heroin use for Caucasians and Hispanics compared to African Americans. 8 While these findings were isolated to a specific region, they do point out that methamphetamine use rates vary depending on the setting and situation. Methamphetamine use is prevalent across genders. Treatment samples indicate that nearly as many women enter treatment for methamphetamine abuse as men. Some women have reported using methamphetamine to cope with issues such as depression, and in attempt to lose weight. 9 Research of adolescent rates of methamphetamine use found that female youth were more likely