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Cariology CARIES DETECTION WITH LASER FLUORESCENCE DEVICES. LIMITATIONS OF THEIR USE Andreas Spaveras 1a , Angeliki Tsakanikou 2b , Frantzeska Karkazi 3c , Maria Antoniadou 1d* 1 2 3 Department of Operative Dentistry, Dental School, National and Kapodistrian University of Athens, Greece Department of Operative Dentistry, Dental School, Semmelweis University, Budapest, Hungary Department of Operative Dentistry, Dental School, Comenius University of Bratislava, Slovakia DMD, Postgraduate Student DMD c MD Dr d DDS, PhD, Assistant Professor a b Received: March 09, 2017 Revised: March 24, 2017 Accepted: April 02, 2017 Published: April 03, 2017 Academic Editor: Dana Cristina Bodnar, DDS, PhD, Professor, “Carol Davila” University of Medicine and Pharmacy Bucharest, Bucharest, Romania Cite this article: Spaveras A, Tsakanikou A, Karkazi F, Antoniadou M. Caries detection with laser fluorescence devices. Limitations of their use. Stoma Edu J. 2017; 4(1):46-53. Abstract Background: Dental caries is one of the most prevalent human diseases worldwide. The modern concept of minimal invasive dentistry includes early detection of incipient caries lesions and its treatment. Several optical and digital detection methods are available. Objective: This literature review presents the utility and limitations of laser fluorescence caries detection devices DIAGNOdent (DD) and DIAGNOdent Pen (DDpen) (KaVo Dental GmbH, Biberach/ Riβ, Germany) for carious lesions on the occlusal surfaces of the permanent dentition. Data sources: All available in vitro and in vivo studies from Google Scholar, PubMed and Scopus machines corresponding to caries, DIAGNOdent, DIAGNOdent Pen and laser fluorescence as key words, were reviewed. Data extraction: Certain limitations of the studies were the inadequate analysis of the experimental protocols, the widespread sample use of the third molar, mistakes in sample handling and the limited number of studies evaluating the detection capability of DD and DDPen for secondary caries. Data synthesis: DD and DDPen are useful devices for caries detection on the occlusal tooth surfaces. Their main advantages are the very high reproducibility of measurements (>0.90), the ease of handling and the quantification and monitoring capacity. Their main limitations are the relatively low specificity for enamel lesions, the necessity of unstained surfaces and absence of plaque and pastes during measurements and the absence of a universal, clinically functional calibration value (COV). Conclusion: Further studies are required for more reliable data analysis and clinical interpretation of the relevant results. Keywords: caries, DIAGNOdent, DIAGNOdent Pen, laser fluorescence, laser. 1. Introduction Dental caries is one of the most widespread human diseases around the world and one of the most important problems in contemporary dentistry. The prevalence of dental caries is higher in the elderly and people of lower socioeconomic status. Nevertheless, it affects not only children but also adults. 1 A substantial decline of caries prevalence has been documented during the last decades, especially in the western world, primarily due to multiple fluoride products and the caries prevention methods available. 2 Nowadays, dental caries in smooth and inter- proximal surfaces of permanent dentition is not so frequent as compared to caries in pits and fissures of the posterior teeth. Most commonly, occlusal caries occur more often in premolars and first molars. 3,4 The difficulty of prompt clinical diagnosis in occlusal areas is due to the anatomical features of these surfaces as well as the use of topical fluoride products. Fluoride can prevent the collapse of the superficial enamel layer and influence the remineralization process. Therefore, large d