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A COMPREHENSIVE REVIEW OF SYSTEMIC FACTORS ASSOCIATED WITH PERI-IMPLANT DISEASES
alpha ( TNF-α ) and interleukin 1-beta ( IL-1β ) release on titanium stimulation were significantly higher among patients with implant failure . The results showed that IL-1β / TNF-α release and number of risk genotypes were significantly associated with implant failure . 71 Vaz et al . 72 examined IL-1 gene clusters in 155 patients with 100 successful implants and 55 unsuccessful implants . The authors concluded that successful implants were associated with a negative genetic test and that unsuccessful implants were associated with a positive genetic test . 72 Casado and colleagues reported that the IL-6 genotype was 1.53 times more likely to convey peri-implant disease if the individuals had the GC
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4 . Conclusion Although systemic diseases such as poorly controlled DM , RA and osteoporosis are significant risk-factors for dental implant failure , proper management of the systemic disorder and optimal oral hygiene may support osseointegration and survival of dental implants in medicallycompromised patients .
Conflict of interest and financial disclosure The author reports no conflict of interest and there was no external source of funding for the present study .
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