Inflammation
CRPCANINE
HPTFELINE
Inflammation & the Acute Phase Response
The acute phase response is a complex, systemic
early-defense system activated by infection, inflammation, trauma and tissue damage or necrosis.
Although nonspecific, it serves as a core of the
innate immune response. It includes physical and
molecular barriers, as well as responses, that serve
to prevent infection, clear potential pathogens, and
further initiate inflammatory processes, ultimately
contributing to resolution and the healing process.
INFLAMMATION
The Acute Phase
Response
Fibrinogen
Liver
Triggers:
Haptoglobin
Serum amyloid
protein
• Infection
• Inflammation
C-reactive protein
• Surgical trauma
• Tissue necrosis
CRP/Hpt: Detect & Monitor Inflammation
As major acute phase proteins, circulating levels of C-Reactive Protein (CRP) in dogs and haptoglobin (Hpt) in cats, rise
rapidly upon the onset of inflammatory stimuli. CRP/Hpt levels also fall rapidly as the inflammatory condition is resolved.
The concentration of CRP/Hpt correlates to both the severity and duration of the inflammatory stimuli.
Damage Associated with
Chronic Inflammation
“Acute Inflammation Defends, Chronic
CANCER
DIA
DIABETES
DIABETES
ABETE
CARDIOVASCULAR
CARDIOV SCU A
CARDIOVASCULAR
Inflammation Kills”
Acute (short-term) inflammation is a vital lifesustaining function. The complex cascade of
events that occurs is needed to initiate a
defense against invading bacteria and to
repair tissue damage that occurs from
trauma, infection, and disease. While acute
inflammation is normally tightly controlled
and part of the healing process, chronic
(long-term) inflammation is both associated
with, and the root-cause of disease. Left
unchecked, chronic inflammation can lead to
disease advancement and even death.
10
S
PANCREATITIS
CHRONIC
INFLAMMATION
AUTOIMM
AUTOIMMUNE
AUTOIMMUNE
D SE SE
DIS ASES
SEAS
DISEASES
IBD
REN
RENAL
NA
RENAL
DIS
DISEASE
SE
DISEASE
ARTHRITIS