ReMed 2018 ReMed Magazine N°4 - Cutting Edge | Page 14

Sciences de la Santé 2. Genetic editing and cancer The development of genomics has allowed a more analytic approach as of the variations of genes ex- pression, and the neo-mutation through the natural selection of the dominant clone of a tumour, with a whole group of reversibility tools, which may even in the later stages of a cancer, diminish its hostility, with the theoretical possibility of a highly selective, effi- cient and adverse effect-free cure for cancer. 3. Cell aging and regeneration therapy The study of embryogenesis and organs morphogen- esis provided a deeper understanding of the genet- ic regulation of these processes, which can open the doors wide towards the development of autogeneic in vitro transplants growing. Besides, the elevation of growth rates of some tissue can be a better mecha- nism to extinct the effect of some degenerative pa- thologies, with the general optic of mastering cell ag- ing and regeneration technology. Figure -3- DNA breaks and pathways of genetic editing 14 Hiver 2018 REFERENCES - Cong L., et al. (2013) Science, 339, 819–823. - Capecchi, M.R. (2005) Nat. Rev. Genet. 6, 507–512. - Fire, A., et al. (1998) Nature, 391, 806–811. - Elbashir, S.Mm, et al. (2002) Methods, 26, 199–213. - Martinez, J., et al. (2003) Nucleic Acids Res. Suppl. 333. - Alic, N, et al. (2012) PLoS One, 7, e45367. - Miller, J., et al. (2005) Mol. Ther. 11, S35–S35. - Mussolino, C., et al. (2011) Nucleic Acids Res. 39, 9283–9293. - Ishino, Y., et al. (1987) J. Bacteriol. 169, 5429–5433. - Barrangou, R., et al. (2007). Science, 315, 1709–1712. - Jinek, M., et al. (2012) Science, 337, 816–821. - Deltcheva, E., et al. (2011) Nature, 471, 602–607. - Sapranauskas, R., et al. (2011) Nucleic Acids Res. 39, 9275–9282. - Nishimasu, H., et al. (2014) Cell, doi:10.1016/j cell.2014.02.001 - Swarts, D.C., et al. (2012) PLoS One, 7:e35888. - Sternberg, S.H., et al. (2014) Nature, doi:10.1038/n- ture13011. - Overballe-Petersen, S., et al. (2013) Proc. Natl. Acad. Sci. U.S.A. 110,19860–19865. - Gong, C., et al. (2005) Nat. Struct. Mol. Biol. 12, 304–312. - Davis, L., Maizels, N. (2014) Proc. Natl. Acad. Sci. U S A, 111, E924–932. - Image d’arrière plan par starline / Freepik