types of LDL-C vary in size through
genetic determination and dietary lipid
intake. All LDLs transport triglycerides
and cholesterol to the tissues but their
atherogenesis varies according to size.
sdLDL-C is therefore a subtype of LDL-
C, and these smaller particles can more
readily permeate the inner arterial wall
and are more susceptible to oxidation (4) .
R E A G E N T S
“ Research indicates
SIZE MATTERS:
THE TRUE WEIGHT OF RISK IN LIPID PROFILING
LDL CHOLESTEROL = 110mg/dL
LOWER RISK
HIGHER RISK
HEALTHY INDIVIDUAL
sdLDL-C 20 mg/dL
CAD PATIENT
sdLDL-C 70 mg/dL
Small-dense LDL Cholesterol (sdLDL-C), a subtype of LDL cholesterol, can more readily permeate the inner arterial wall
making sdLDL-C particularly atherogenic. Research indicates that individuals with a predominance of sdLDL-C have
a three-fold increased risk of myocardial infarction. Until recently, the primary methods of assessing a patients sdLDL-