Pharmaceutical & Cosmetic Review May 2017 | Page 40

Pharmaceutical Focus // Technology

The right shot in direct compression

In billiards , a discreet balance of resilient and inelastic collision is needed to pocket the opponent โ€™ s balls . A similar principle is important in the transformation of powders into coherent solid bodies such as tablets . This plastically deforms particles in combination with fractionating while brittle materials tend to develop outperforming synergies .

MicroceLac 100 is one such synergistic , well-balanced material . It is also known as a co-processed excipient consisting of 75 percent alpha-lactose-monohydrate and 25 percent microcrystalline cellulose ( MCC ). MicroceLac 100 is manufactured by spray-drying and clearly outperforms the physical admixture regarding constant hardness through a fi xed ratio of lactose and MCC . It shows a remarkable compaction profi le , even in high dosage formulations .
Benefits and areas of application
Meggle produces this fi ller-binder , which is available in South Africa from Amchem . As a highly renowned enterprise , Meggle enjoys an excellent reputation and its excipients are used in more than 100 countries .
Typical features of MicroceLac 100 include its excellent weight consistency at various compaction speeds and a low aggregation tendency . It can be used for all direct compression formulations from low to high dosage at optimum output . It also helps to stabilise content uniformity trough adhesion of active ingredients and is most appreciated in highly effective , low dosage formulations , such as oral contraceptives .
MicroceLac 100 can improve the rheological properties of powder blends while serving as a means for troubleshooting in poorly fl owing preparations , including micronised active ingredients .
MicroceLac 100 is best suited for use in oblong and small tablets . A letter of authorisation for Drug Master File type IV and a Meggle monograph are available on request . ยท
Amchem โ€“ www . amchem . co . za Meggle โ€“ www . meggle-pharma . com
Thureya Sarlie , Commercial Contact Mobile + 27 ( 0 ) 83 457 6575
Tel + 27 ( 0 ) 11 922 1639 Email thureya . sarlie @ chemsystems . co . za
www . chemsystems . co . za
Chemsystems
40 | MAY 2017 | P C Review