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PERIODONTICS Silk fibroin can be used in implant therapy as a recent (2014) study suggests (53). Silk fibroin from non-mulberry source was immobilized on titanium surface, which led to improved cell adhesion and differentiation, facilitating a better osteogenesis on orthopedic implants (53). Peri-implant defects can be successfully repaired using silk fibroin powder mixed with Choukroun platelet-rich fibrin (PRF) (54). The study on rabbits concluded that after inserting dental implants and filling the peri-implant defects with silk fibroin powder and Choukroun PRF, the mean new bone formation is statistically significantly higher than the one of the control (54). Another silk fibroin and 4-hexylresorcinol incorporation membrane was fabricated to fill peri-implant defects and was succesfully used in rabbits (55). The silk fibroin and 4-hexylresorcinol membrane lead to 18.3 ± 1.9 mm mean bone regeneration, almost double than the control group that showed 9.3 ± 0.9 mm of new bone in the histomorphometric analysis (55). Moreover, premineralized silk scaffold was used as a substrate for bone marrow stromal cells to construct tissue-engineered bone for mandibular bony defects in a vrat model (56). Tissue engineered buccal mucosa was obtained from oral keratinocytes and autologous canine fibroblasts seeded onto silk fibroin matrices (57) and the oral keratinocytes and fibroblasts exhibited good biocompatibility with the silk fibroin matrices (57). Additionally there were develloped silk fibroin materials for wound repair in the buccal mucosa (24). Ninety wounds to the bucal mucosa applied to ratss were treated with silk fibroin films and scaffolds. the wound shrinkage was significantly lower as well as the growth of mucosal epithelial cells was enhanced without any local or systemic immunological incompatibility (24). In summars , silk fibroin is a promising material for future regeneration techniques in medicine. Dentistry may very well profit a lot from the different silk fibroin derived materials which are in tests nowadays since a vast majority of the studies concentrate on the regeneration of the osteodental tissues. Acknowledgements: This work received financial support through the project „CERO - CAREER PROFILE: ROMANIAN RESEARCH”, contract no. HRD / 159 / 1.5 / S / 135760, financed from the European Social Fund Operational Programme Human Resources Development 20072013. Bibliography 1. Meinel L, Betz O, Fajardo R, Hofmann S, Nazarian A, Cory E, Hilbe M, McCool J, Langer R, Vunjak-Novakovic G, Merkle HP, Rechenberg B, Kaplan DL, Kirker-Head C. Silk based biomaterials to heal critical sized femur defects. Bone. 2006;39(4):922-931. 2. Vepari C, Kaplan DL ,Silk as a Biomaterial. Prog Polym Sci. 2007;32(8-9):991-1007. 3. Wang X, Wenk E, Matsumoto A, Meinel L, Li C, Kaplan DL. Silk microspheres for encapsulation and controlled release. J Control Release. 2007;117(3):360-370. 4. Meinel L, Hofmann S, Karageorgiou V, Zichner L, Langer R, Kaplan D, Vunjak-Novakovic G, Engineering cartilagelike tissue using human mesenchymal stem cells and silk protein scaffolds. Biotechnol Bioeng. 2004;88(3):379-391. 5. Karageorgiou V, Meinel L , Hofmann S, Malhotra A, Volloch V, Kaplan D. Bone morphogenetic protein-2 decorated silk fibroin films