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SILK FIBROIN AND POTENTIAL USES IN REGENERATIVE DENTISTRY - A SYSTEMATIC REVIEW Table1. Applications of silk fibroin scaffolds in osteo-dental regeneration. Tissue Regenerated Scaffold Cells Year /Study cartilage-like tissue silk fibroin scaffold human mesenchymal stem cells (4) bone-like tissue silk fibroin scaffold human bone marrow stem cells (6) ligament silk fibroin scaffold human periodontal ligament fibroblasts  (31)  neo-osteochondral tissue silk fibroin scaffold human bone marrow stromal cells (16) mineralized dental tissue (osteodentine) silk fibroin scaffold rat tooth bud cells (52) However, in another study the nanohydroxyapatite alone resulted in significantly higher bone regeneration than the grafting with the combination of silk-fibroin and nanohydroxyapatite (46). In New Zealand calvarial defects of white rabbits treated with nanohydroxyapatite showed 40.16% ± 8.27% new bone formation compared to 16.62% ± 3.05% in the hydroxyapatite graft with silk fibroin scaffold (46). Additionally in the same study, even the control led to better results, (25.66% ± 10.98%) than the silk fibroin group (46). Other authors supported the ideea that the hydroxyapatite/ silk fibroin scaffold could be used with better results than the hydroxyapatite scaffold alone (47). The composite hydroxyapatite/regenerated silk fibroin scaffold supported a significantly increased alkaline phosphatase activity and cell viability than the hydtoxyapatite scaffold alone (47). Also composite silk scaffolds with nanohydroxyapatite crystals indicated good results in bone regeneration (21). Composite bi