SILK FIBROIN AND POTENTIAL
USES IN REGENERATIVE DENTISTRY - A SYSTEMATIC REVIEW
Table1. Applications of silk fibroin scaffolds in osteo-dental regeneration.
Tissue Regenerated
Scaffold
Cells
Year /Study
cartilage-like tissue
silk fibroin scaffold
human mesenchymal stem cells
(4)
bone-like tissue
silk fibroin scaffold
human bone marrow stem cells
(6)
ligament
silk fibroin scaffold
human periodontal ligament fibroblasts
(31)
neo-osteochondral tissue
silk fibroin scaffold
human bone marrow stromal cells
(16)
mineralized dental tissue
(osteodentine)
silk fibroin scaffold
rat tooth bud cells
(52)
However, in another study
the nanohydroxyapatite alone resulted in significantly
higher bone regeneration than the grafting
with the combination of silk-fibroin and nanohydroxyapatite (46). In New Zealand calvarial
defects of white rabbits treated with nanohydroxyapatite showed 40.16% ± 8.27% new
bone formation compared to 16.62% ± 3.05% in
the hydroxyapatite graft with silk fibroin scaffold
(46). Additionally in the same study, even the
control led to better results, (25.66% ± 10.98%)
than the silk fibroin group (46). Other authors
supported the ideea that the hydroxyapatite/
silk fibroin scaffold could be used with better
results than the hydroxyapatite scaffold alone
(47). The composite hydroxyapatite/regenerated
silk fibroin scaffold supported a significantly
increased alkaline phosphatase activity and cell
viability than the hydtoxyapatite scaffold alone
(47). Also composite silk scaffolds with nanohydroxyapatite crystals indicated good results in
bone regeneration (21).
Composite bi