MSC - Page 33

SILK FIBROIN AND POTENTIAL USES IN REGENERATIVE DENTISTRY - A SYSTEMATIC REVIEW within the field of tissue engineering (12). Silk fibroin could act as a scaffold material, a substrate on which cells can thrive and receive stimuli such as growth factors that guide the differentiation process of cells (7), through controlled drug delivery. The compressive modulus of gas foamed silk fibroin scaffolds was superior as compared to scaffolds prepared from collagen, chitosan, PLGA and PLLA, materials that are intensively studied as scaffolds materials (13). A variety of cells were cultured on fibroin scaffolds and maintained their viability. Endothelial cells were cultured on the silk fibroin and the cells attached and proliferated, forming after a week microvessellike structures (14). Also a silk fibroin film and BMP-2 induced osteogenic differentiation of human bone marrow stromal cells (5). Additionally, amniotic fluid stem cells were also seeded on silk bioengineered constructs and were able to differentiate into osteoblas