SILK FIBROIN AND POTENTIAL
USES IN REGENERATIVE DENTISTRY - A SYSTEMATIC REVIEW
within the field of tissue engineering (12). Silk
fibroin could act as a scaffold material, a substrate
on which cells can thrive and receive stimuli such
as growth factors that guide the differentiation
process of cells (7), through controlled drug
delivery. The compressive modulus of gas foamed
silk fibroin scaffolds was superior as compared to
scaffolds prepared from collagen, chitosan, PLGA
and PLLA, materials that are intensively studied as
scaffolds materials (13).
A variety of cells were cultured on fibroin scaffolds
and maintained their viability. Endothelial cells were
cultured on the silk fibroin and the cells attached
and proliferated, forming after a week microvessellike structures (14). Also a silk fibroin film and BMP-2
induced osteogenic differentiation of human bone
marrow stromal cells (5). Additionally, amniotic fluid
stem cells were also seeded on silk bioengineered
constructs and were able to differentiate into
osteoblas