PHOTO: LOIC PRAVAZ
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reproductible d’un centre à l’autre et per-
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New criteria for Parkinson’s diagnosis
non spécialisés dans la maladie de Parkin-
University Health Centre (MGH-MUHC), the rate of misdiagnosis for PD can be as high
mettre à un plus grand éventail de cliniciens
son à fournir un diagnostic exact à leurs
patients. »
Par exemple, les patients atteints du
parkinson perdent souvent l’odorat, un
symptôme plus rare en présence d’autres
maladies. Ce symptôme fait désormais partie
According to Dr. Ron Postuma, neurologist at the Montreal General Hospital of the McGill
as 25 per cent. “Full diagnostic certainty is impossible during life because it closely resembles other neurological disorders,’’ explains Dr. Postuma, who has been working for
15 years on Parkinson’s. “On top of creating distress in patients, mistaken diagnosis also
creates a challenge for researchers as the data collected in clinical studies can become
compromised in their pool of subjects.’’
Currently, diagnosis of Parkinson’s can only be established through an analysis of
des critères pour aider les médecins à poser
medical history and a neurological examination by a clinician with expertise in move-
mettent de concilier l’information au moyen
by an international group of experts, under the umbrella of the International Parkinson
le diagnostic. Les nouveaux critères perde caractéristiques négatives, les « signaux
d’alarme », qui plaident contre un diagnostic
de parkinson, et de caractéristiques positives,
ment disorders – no objective test for the disease exists. However, a recent research led
and Movement Disorder Society (MDS), may pave the way for improving diagnosis and
advancing treatment of Parkinson’s.
“In light of the latest scientific insights and technological advances, we were able
qui plaident pour un tel diagnostic. Pour écar-
to establish a new list of criteria based on expert clinical diagnosis,” says Dr. Postuma,
signaux d’alarme doivent être contrebalan-
logical Hospital/Institute, who was co-chair of the MDS task force with Dr. Daniela Berg
ter un diagnostic probable de parkinson, les
cés par des critères positifs.
Des recherches axées sur
un diagnostic rapide
clinical-scientist from the Research Institute of the MUHC and from The Montreal Neuro-
from Tubingen, Germany. “Our aim was to create a benchmark that will systematize the
diagnostic process, make it reproducible across centres and enable a wider range of non
PD-specialized clinicians to provide patients with an accurate diagnosis.”
For example, the sense of smell is commonly lost in PD patients but uncommonly lost
L’équipe de recherche a poussé son analyse
in alternate diseases. Now, it is included in the diagnostic criteria as another way to help
la maladie par stades, afin de se concentrer
cluding negative features called ‘red flags’ that argue against a diagnosis of PD and posi-
plus loin. Elle propose une classification de
sur les premiers stades de la maladie de
Parkinson avant même que les patients g
physicians make the diagnosis. The new criteria has ways to balance information by intive features that argue for a PD diagnosis. Red flags rule out probable PD diagnosis only
when they cannot be counterbalanced by supportive criteria. gg
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