Enhance your
patients’ outcome
4
2
Methionine in return
produces
S-adenosylmethionine 2
1
5 Methyl-THF is
required to convert
homocysteine to
methionine 1
which also
requires
Vitamin B12 1
3
Folic acid taken
with anti-depressant
medication improves the
treatment outcomes of
patients 4
S-adenosylmethionine
facilitates the synthesis
of neurotransmitters
including: dopamine
& serotonin 3
Improved HAM-D #
scores
6.8 vs 11.7 in placebo
group* 4
* 500 mcg folic acid + 20 mg fluoxetine daily
# Hamilton depression rating scale
Essential for normal cell division 5
References: 1. Mahan, L.K. et al. Krause’s Food and the Nutrition Care Process. 13th edition. United States of America. Saunders, an imprint of Elsevier Inc.2012. Folate. P82-85.2. Bradley A, Maron M.D et al. National Institute
of Health. The Treatment of Hyperhomocysteinemia. Annu Rev Med.[Online]. 2009 [cited 2016 Oct 14] ; 60:39–54. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2716415/pdf/nihms-84951.pdf.4. 3. Mischoulon
D. Update and Critique of Natural Remedies as Antidepressant Treatments. Obstet Gynecol Clin North Am. [Online]. 2009 [cited 2016 Oct 14] ; 36(4): 789–807. Available from: https://www.ncbi.nlm.nih.gov/pubmed/19944301.
4. Coppen A, Bailey J. Enhancement of the antidepressant ac