Masters of Health Magazine September 2018 - Page 48

Important detoxification enzymes are disrupted by Glyphosate, such as Glutathione and CYP P450. Problems with the activity of these enzymes are strongly associated with autism spectrum disorders, mental illness, auto-immune disorders, celiac disease, heart disease, diabetes and cancer. All of these conditions have in common heightened inflammatory responses, accumulation of waste products and acidosis leading to cell energy starvation and dysfunctional detoxification systems, blocked by heavy metals like aluminium together with chemicals like glyphosate and fluoride.

Glutathione Detoxification Enzyme for pH Balance – Hindered by Glyphosate and Heavy Metals

Glutathione (GSH) is a powerful antioxidant fat-soluble enzyme used by the liver in detoxification to neutralise free radicals and prevent cellular damage. The three sulphur-containing amino acids - glutamine, glycine and cysteine - used by the body to make glutathione, are also a vulnerable target for heavy metals. When the body is overloaded with toxic metals there are not enough of the sulphur-containing amino acids available to make glutathione. In other words, the toxic metals block the body’s ability to detoxify.

Magnesium is required to produce glutathione, as glutathione is a protein. Glutathione is found in every cell, but more commonly in liver cells, as the liver is the main detoxification organ and has to do most of the heavy lifting.

GSH is thought to participate in the detoxification of acidic metabolism by-products, as well as inflammatory acidic by-products such as reactive oxygen species (ROS), including those produced by the action of another detoxification enzyme - cytochrome P-450.

It is shown that GSH transferase B inhibits lipid peroxidation (ie, acidification). GSH is important for pH balance and neutralisation of acids in order to maintain our ‘good’ cholesterol – HDL (high density lipoprotein).

As the brain is largely composed of cholesterol fats it also needs all the help it can get to detoxify. Scientists have found that sulphur amino acid deficiency, which are the precursors to production of glutathione enzyme, depresses the brain glutathione level. [7] This makes it harder for the brain to eliminate waste products and chemical toxins.

CYP P450 Detoxification Enzyme for Elimination of Toxins – Suppressed by Glyphosate

Glyphosate inhibits cytochrome P450 enzymes (CYP), which are involved with cleaning up and eliminating environmental toxins, activating vitamin D3, catabolizing vitamins and maintaining bile-acid production for digestion and sulphate supplies to the gut.

Cytochrome P450 proteins, named for the absorption band at 450 nm of their carbon-monoxide-bound form, are one of the largest superfamilies of enzyme proteins. The P450 genes (also called CYP) are found in the genomes of virtually all organisms, but their number has exploded in plants.[8]

They are involved in energy metabolism and used in plants and humans against chemical assault and contribute to vital processes such as carbon source assimilation, biosynthesis of hormones and structural components of living organisms, as well as carcinogenesis and degradation and elimination of xenobiotics (ie, toxins).