Introduction
Despite a clear concept of cervical cancer (cytological, colposcopic) it still remains one of the topical issues of gynecology. According to the International Agency for Research on Cancer every year 500,000 new cases of cervical cancer are registered in the world, 5,000 new cases per year in Ukraine, and the situation in Ukraine is gradually deteriorating [3].
The current socio-economic situation in Ukraine is combined with an increase in the incidence of young women under 40 years of age. Particularly marked increases in the incidence of cervical cancer in women under the age of 29, namely, an annual increase of 2.1% (!). A similar trend in increasing the incidence of women of reproductive age is observed in other countries. According to the American Cancer Society, in the US in 2016, 47% of cervical cancer patients are women up to 35 years of age.
Timely diagnosing, the use of effective methods of treatment the pathology of the cervix is a reliable guarantee of the prevention of cervical cancer. The surgery with the introduction of modern methods (diatermoconification, cryodistruction, radio-wave and laser evaporation, argonoplasmic coagulation) is widely used for cervical pathology now. The choice of method of treatment depends on the clinical form, the age of the patient, reproductive intentions, the presence of previous interventions on the cervix [8; 9].
The main problem which occurs in the case of surgical treatment is the risk of developing complications and the possibility of relapse of the disease, which prompts the search for effective rehabilitation methods after surgery.
Reducing the intensity of the trophic and regenerative processes of the cervical epithelium in the postoperative period poses a risk of postoperative complications, leads to inferior epithelization and deformation of the tissues of the cervix and, consequently, to relapse the disease. To improve the efficacy of curing the disease, it is advisable to create favorable conditions for the flow of trophic and regenerative processes of the uterine cervix epithelium during the rehabilitation stage after surgical interventions on the cervix [5; 10].
Thus, the use of rehabilitation measures after surgical interventions on the cervix is an important and necessary step in the treatment of cervical pathology in order to improve reproductive health of women.
At the same time, complex rehabilitation of patients of reproductive age with cervical cancer precursors should aim at early restoration of sexual, reproductive and social functions of women. Thus, the actual task of modern oncology and oncogynecology is the development of effective pathogenetically based methods of postoperative rehabilitation of patients with cervical intraepithelial neoplasia, which reduces the number of relapses, as well as maximally quickly restore the reproductive and sexual function of women.
The purpose of the study was to find the clinical efficacy of the use of the suppositories containing 0.5 g of amaranth oil, squalan 20mg, Vit E 2mg, Vit A 95mcg, (Ukraine) in the rehabilitation of patients with cervical intraepithelial neoplasias CIN II after diathermoconification of the cervix.
Material and methods: 50 patients of reproductive age with morphologically verified cervical intraepithelial neoplasia CIN II were examined in gynecological department of the University Clinic Odessa National Medical University, according to the "Unified clinical protocol of the primary, secondary (specialized), tertiary (highly specialized) medical aid" Dysplasia of the cervix of uterus, Cancer of the cervix of uterus".