Lab Matters Summer 2018 - Page 43

APHL 2018 Annual Meeting Poster Abstracts Whole-Genome Sequencing of Carbapenemase-producing Klebsiella pneumoniae Isolates Recovered from a CRE Colonization Investigation E. Snavely 1 , E. Nazarian 1 , D. Baker 1 , J. Bodnar 1 , K. Cummings 1 , P. Lapierre 1 , K. Mitchell 1 , S. Morris 1 , J. Shea 1 , C. Wagner 1 , D. Wroblewski 1 , C.B. Kinsey 2 , L. Dettinger 2 , D. Xia 2 , K. Musser 1 ; 1 Wadsworth Center, New York State Department of Health, Albany, NY, 2 Pennsylvania Department of Health, Harrisburg, PA Presenter: Emily Snavely, PhD, Wadsworth Center, New York State Department of Health, Albany, NY, Phone: 605.431.5044, Email: emily.snavely@health.ny.gov PublicHealthLabs @APHL APHL.org A. Ojebode, L. Leach and S. Chaturvedi; Wadsworth Center, New York State Department of Health, Albany, NY Candida auris is an emerging multidrug-resistant yeast, causing invasive healthcare-associated infections with high mortality in several countries including the US. Mortality associated with C. auris infections are found to be common among the elderly, severely ill patients with indwelling catheters and hematological malignancies. Conventional blood culture considered as “gold standard” for candidemia identification, is time-consuming and takes at least 5-7 days. In certain instances, C. auris has been misidentified as C. haemulonii or C. sake by this method as well, t \XHXZ[]X\B܈H؛][\XYو\YX\ ݙ\YH\H؛[\H][^Y\X[H][YX[ ][YHԈ\^H[BXܘ]ܞH܈H[Y][ۈو\HX]^܈H]X[ۂوˈ]\\ˈH[Z]و]X[ۈوH\^H\]Hˈ]\\ѕK”ԈXX[ۈ][YXY[H]Hو HLIKH\^B\YH\XXH\]XYۜ\[\[][[ۈY\[^\و\[ˈݙ\[ \\^H\\Y]B\X\[[YHو^\\\\Y x$^\][\H[\[H]\\X܈X[Y[]Y[]˂]\\[XY[Y[ZXH\[\H[\[Y[][ۈوXXšX[YX\\\۝HXYو\[Y\[][YYB\\[YX\][\[\^[[HڙXKT U T KYܝ[B\][ܚ]H\\Y[وX[ [[KKۙNLN MK[XZ[^[[KڙXPX[ K݂YXYXX[]Hو[YH]\\[\[YBXY\HPSKUш^X[ۜŠ\]HXX[[X[\\X\K BT[\[H MTY[X\\\^N\[\H[B ܘ[[ \[[ˈ[X \X][ۈوXXX[Xܘ]ܚY\[\[Q[X[ێ]\H LYX\TYZ[\\HY[X\]\٘X[ۈ\^HYZ[\ۜ\[YYXH[TY[X\ˈ[ MHY[X\\\^H\YZ[\\Y]Y[H]\و[X\H K M[XX\H  M˂Y]Έ\^H\[[TY[X\ˈHY[X\\\\Y[ݚYYH۝[܈H]Y\[ۜ[YY]\\و]Y\[ۜ[Hۈ\\[HX[[YHوTY[X\\[Y[X\[Y[Y[[[H]\K\^H]Y\[ۜݙ\YY[X\&H]\٘X[ۈ][]H\Y]BوTX[\X\ˈ\^H\YZ[\\YHT8&\’[]][ۘ[\X\ܘ[K\[Έ\ۜH]H܈H\^H\ IH JKوH B\ۙY HY\\و\ۙ[\H[B]H[]][ۘ[Y[X\]YܞH LKJK]\٘X[ۈ]TY[X\\\\HY ]NIHو\ۙ[^Z[^H\H]\ٚYY]Z\[Y]ˈZ]\KH]\٘X[ۂ][܈[\X[ۜ]TY\MˌH ^[[܂[[Y\ NPPUT B[\YKKY[YH\]Y[[ H\\Yœ]X][H[[^H\\[[X\K\X[\\[[KB\\[[\ؘX\XXXYH  PԑJH\]\ˈ\H\]\\HXݙ\Y\[H[][[H\^H]H L XYۙ\H\HX[]H ъH[[[[XK\H\\ق PԑH\Hۙ\YY]H[\܈\X\H۝\˜H \]]HXY[H][[ۚXYK\HܝX\Y[ۘ[[[ZXܛؚX[\\[HXܘ]ܞH]ܚ THXܘ]ܞKBYܝ[\\[Y\ܛHԑHۚ^][ۈ\[š[\ۜHH]X[ۈو PԑK][\^X[ ][YHԂ\^\\ܛYY[\Xܘ]ܞH]XYHH[H[ L›و X[X[XX[Y[XYH\Y[وBHX[]N L[\]YHˈ][[ۚXYH\]\\HXݙ\Y\[˜ۚ^][ۈ[\HY]H LوHܚY[[ LX[Y[˂H]X]H[[\\و\H\]\H]\Z[Y[\]\H\]Y[H\H N  N HH][[\\]Y[B\[[[\\ˈ[[\\[]\Z[Y][\]\\B]]H܈HH L\X[ X\\X]Y]H\ZY]\ܜ\[[ZXܛؚX[\\[H]\Z[[[Y[™[\]ۙ\[Z[XYK[ۘ[ZYH[[Y][B\\[K\]K[X[X\H[Z[Y\Y[YYY\[\[[\\[YHH  JKSH L JH[ L JK[[ZXܛؚX[\\X[]H\[HZXܛ[][ۈ[X]YLHو L\]\Xݙ\Y\H\\[\\[[K[Z\[[B[Y\[[K\H LH\]\\H[]]H[\Y܈[\X\\[[X\HX[ۈ\[H[YYY\\[[H[X]][ۈY] PSJK[\Y][ۜوB[HPSHY]]K\\[[K\\\XH\]H]X[YBۜ[H]]][ۈ[HH[H][XYH[X]\BۋHXZܚ]Hو\]\[\YH Lو LH\B[\\[[Y][K[[Y]^H T V K[۝\  وH L\]\\H[]]H[[Z[XYB[X[X[ۙ]T V H\\X[]Hٚ[BY\[\و\H\]\ܜ\ۙ]HX[Hو [\]ۙ\[Z[XYH\\[H[ [\ۛۂH[Y[[Y][H[[ۘ[ZYH\\[N\B[\\H\[[H]HوH\ L\]\ˈB[[\\]X[Y \\ܛYYHH\]\]H[XZ[[Œو L\]\[[]Y [\\[KӔ[[\\šY[YYY H[[]Y\]H[\X\^Y LH\]\[ \\ۙH\\۝Z[Y\]\[HH\\\\™ܛYYH \]\ˈ۝[YYܚۈ\YH[[[Z[\YY\[۝X]HH[\[[وH[Z\[ۈق[Y\[ PԑHZ[[[\X[X[ۈ۝X]]Y\˂[Y][ۈوHX[ ][YHԈ\^H܈\Y]X[ۂو[Y\[][YY\\\[ˈ]\\H