Lab Matters Spring 2019 - Page 13

ENVIRONMENTAL HEALTH Storing Samples and Data for Future Use Residual DBS are a potentially valuable resource for research, but the cost of storage, retrieval and preparation of DBS for biomonitoring can be substantial. The lack of storage guidelines for residual DBS around physical conditions like temperature and humidity, in combination with issues around privacy and consent, currently limit the use of residual DBS for biomonitoring. Looking to the future, DBS and other non-conventional matrices such as amniotic fluid, meconium, cord blood, placenta and umbilical cord have the potential to be matrices for assessing exposure to select environmental chemicals. Newly emerging analytical approaches offer the possibility of analyzing DBS spiked with pharmaceutical compounds with minimal sample preparation and PublicHealthLabs @APHL extraction steps. These quantitative methods, already applicable in the pharmaceutical field for analyzing whole blood, offer exciting promise for the analysis of DBS for biomonitoring purposes. High-quality analytical methods already permit the determination of target environmental chemicals in DBS. However, limited data exist on the suitability of DBS for biomonitoring purposes, particularly for chemicals with widespread commercial and industrial use. As validated protocols are developed for the collection, handling, shipping and storage of DBS to preserve the integrity of both DBS and the target analytes, they will help assure valid generation and interpretation of biomonitoring data. Further research will provide critical data to determine the suitability of DBS for epidemiologic studies to assess exposures to environmental chemicals. Since 1999, NHANES has included an ongoing exposure assessment of the US population to select environmental chemicals. CDC’s Updated Tables, January 2019 presents nationally representative and cumulative biomonitoring data gathered from 1999 through 2016, including all the data from each previous National Report on Human Exposure to Environmental Chemicals. n Spring 2019 LAB MATTERS 11