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102 K. W. Jang et al. study was observed only after a short-term exercise period of 2 weeks, and the effect was only measured immediately after the treatment period ended. We could not distinguish this effect from spontaneous recovery of dysphagia after stroke. The current study could not reveal the effect of additional MIE exercise on all the phases of the swallowing process. As swallowing and coughing functions have different characteristics ac- cording to the stroke lesion types (26), well-designed studies are needed to evaluate the effect of MIE ex- ercise according to the stroke lesion type. Finally, the comparisons in this study were performed on a rela- tively smaller number of patients, with no long-term follow-up records. Thus, further research on a larger sample size and long-term follow-up are required to confirm the results of this study. Conclusion The MIE exercise using cough assist has a therapeutic effect on VPI in subacute stroke patients with dyspha- gia. Furthermore, this MIE exercise affects both swal- lowing and coughing functions in patients after stroke. A combination rehabilitation therapy including addi- tional MIE exercise was more effective for alleviating the symptoms of VPI than conventional rehabilitation therapy alone. This therapy is easy to apply in the clini- cal setting, and can be a useful therapeutic strategy for VPI with dysphagia in patients with stroke. The authors have no conflicts of interest to declare. REFERENCES 1. Martino R, Foley N, Bhogal S, Diamant N, Speechley M, Teasell R. Dysphagia after stroke: incidence, diagnosis, and pulmonary complications. Stroke 2005; 36: 2756–2763. 2. Flowers HL, Silver FL, Fang J, Rochon E, Martino R. The incidence, co-occurrence, and predictors of dysphagia, dysarthria, and aphasia after first-ever acute ischemic stroke. J Commun Disord 2013; 46: 238–248. 3. Smithard DG, O’Neill PA, Parks C, Morris J. Complications and outcome after acute stroke. Does dysphagia matter? Stroke 1996; 27: 1200–1204. 4. Katzan IL, Cebul RD, Husak SH, Dawson NV, Baker DW. The effect of pneumonia on mortality among patients hos- pitalized for acute stroke. Neurology 2003; 60: 620–625. 5. Ward K, Seymour J, Steier J, Jolley CJ, Polkey MI, Kalra L, et al. Acute ischaemic hemispheric stroke is associated with impairment of reflex in addition to voluntary cough. Eur Respir J 2010; 36: 1383–1390. 6. Smith Hammond CA, Goldstein LB, Zajac DJ, Gray L, Davenport PW, Bolser DC. Assessment of aspiration risk in stroke patients with quantification of voluntary cough. Neurology 2001; 56: 502–506. 7. Kimura Y, Takahashi M, Wada F, Hachisuka K. Differences in the peak cough flow among stroke patients with and without dysphagia. J UOEH 2013; 35: 9–16. 8. Smith Hammond CA, Goldstein LB, Horner RD, Ying J, Gray L, Gonzalez-Rothi L, et al. Predicting aspiration in patients with ischemic stroke: comparison of clinical signs www.medicaljournals.se/jrm and aerodynamic measures of voluntary cough. Chest 2009; 135: 769–777. 9. Bianchi C, Baiardi P, Khirani S, Cantarella G. Cough peak flow as a predictor of pulmonary morbidity in patients with dysphagia. Am J Phys Rehabil 2012; 91: 783–788. 10. Pitts T, Rose MJ, Mortensen AN, Poliacek I, Sapienza CM, Lindsey BG, et al. Coordination of cough and swallow: a meta-behavioral response to aspiration. Respir Physiol Neurobiol 2013; 189: 543–551. 11. Vose A, Nonnenmacher J, Singer ML, Gonzalez-Fernandez M. Dysphagia management in acute and sub-acute stroke. Curr Phys Med Rehabil Rep 2014; 2: 197–206. 12. Glade RS, Deal R. Diagnosis and management of velopha- ryngeal dysfunction. Oral Maxillofac Surg Clin North Am 2016; 28: 181–188. 13. Folkins JW. Velopharyngeal nomenclature: incompetence, inadequacy, insufficiency, and dysfunction. Cleft Palate J 1988; 25: 413–416. 14. Cahill LM, Turner AB, Stabler PA, Addis PE, Theodoros DG, Murdoch BE. An evaluation of continuous positive airway pressure (CPAP) therapy in the treatment of hypernasality following traumatic brain injury: a report of 3 cases. J Head Trauma Rehabil 2004; 19: 241–253. 15. Kuehn DP, Moon JB, Folkins JW. Levator veli palatini muscle activity in relation to intranasal air pressure variation. Cleft Palate Craniofac J 1993; 30: 361–368. 16. Kuna ST, Sant’Ambrogio G. Pathophysiology of upper air- way closure during sleep. JAMA 1991; 266: 1384–1389. 17. Chatwin M, Ross E, Hart N, Nickol AH, Polkey MI, Simonds AK. Cough augmentation with mechanical insufflation/ exsufflation in patients with neuromuscular weakness. Eur Respir J 2003; 21: 502–508. 18. Palmer JB, Kuhlemeier KV, Tippett DC, Lynch C. A protocol for the videofluorographic swallowing study. Dysphagia 1993; 8: 209–214. 19. Sallum RA, Duarte AF, Cecconello I. Analytic review of dysphagia scales. Arq Bras Cir Dig 2012; 25: 279–282. 20. Han TR, Paik NJ, Park JW. Quantifying swallowing fun- ction after stroke: a functional dysphagia scale based on videofluoroscopic studies. Arch Phys Med Rehabil 2001; 82: 677–682. 21. Rosenbek JC, Robbins JA, Roecker EB, Coyle JL, Wood JL. A penetration-aspiration scale. Dysphagia 1996; 11: 93–98. 22. Suarez AA, Pessolano FA, Monteiro SG, Ferreyra G, Capria ME, Mesa L, et al. Peak flow and peak cough flow in the evaluation of expiratory muscle weakness and bulbar impairment in patients with neuromuscular disease. Am J Phys Med Rehabil 2002; 81: 506–511. 23. Sylvester DC, Karkos PD, Vaughan C, Johnston J, Dwivedi RC, Atkinson H, et al. Chronic cough, reflux, postnasal drip syndrome, and the otolaryngologist. Int J Otolaryngol 2012; 2012: 564852. 24. Kummer AW. Speech therapy for errors secondary to cleft palate and velopharyngeal dysfunction. Semin Speech Lang 2011; 32: 191–198. 25. Kulnik ST, Birring SS, Hodsoll J, Moxham J, Rafferty GF, Kalra L. Higher cough flow is associated with lower risk of pneumonia in acute stroke. Thorax 2016; 71: 474–475. 26. Lee SJ, Lee KW, Kim SB, Lee JH, Park MK. Voluntary cough and swallowing function characteristics of acute stroke patients based on lesion type. Arch Phys Med Rehabil 2015; 96: 1866–1872. 27. Pitts T, Bolser D, Rosenbek J, Troche M, Okun MS, Sapi- enza C. Impact of expiratory muscle strength training on voluntary cough and swallow function in Parkinson disease. Chest 2009; 135: 1301–1308. 28. Sivasothy P, Brown L, Smith IE, Shneerson JM. Effect of manually assisted cough and mechanical insufflation on cough flow of normal subjects, patients with chronic obstructive pulmonary disease (COPD), and patients with respiratory muscle weakness. Thorax 2001; 56: 438–444.