January/February 2018 AQHA Digital_Website March_April_2018 | Page 28

BIOGNOSIS Joining the dots between the Equine Intestinal Microbiota, Herbs, Soil and chronic diseases such as Laminitis and Equine Metabolic Syndrome. Copyright by Catherine Cox-Mcdowell 2017 “The equine intestinal tract contains a complex microbial population (microbiota) that plays an important role in health and disease. Despite the undeniable importance of a ‘normal’ microbiota, understanding of the composition and function of this population is currently limited. As methods to characterize the microbiota and its genetic makeup (the microbiome) have evolved, the composition and complexity of this population are starting to be revealed” Marcio Costa- DOI: 10.1017/S1466252312000035 · Source: PubMed There is now plenty of research that is looking at the micro- biota’s genetic makeup. What is absolutely fascinating to me is the realisation that the genetic material of the Microbiome contributes to upwards 60% of the genetic material of the horse! This topic is a massive one, and to take it on requires a dedication to years of research .For the purpose of this article I am limiting the discussion to the microbiota, natural systems and chronic disease. I just love reductionist science! Breaking life down into smaller and smaller particles seems to be the main aim of researchers, trying to find the one single pathogen, microbe or gene that will provide the key to unlocking ill health. Unfortunately this may lead to propaganda science and excessive supplement recommendations in a readymade market for a new brand of pro biotic that addresses these deficiencies. Inoculation of the gut is not a new idea – pro biotics are very popular in both people and animals, and very profitable for the pharmaceutical companies that manufacture them. Whilst its very interesting Page 28 • The Australian Quarter Horse Magazine • March • April • 2018 Photos: Shutterstock looking at the equine microbiome under the microscope, there are some very obvious connections that we need to make here in order for this information to be remotely of value to us as managers of our domesticated horses. Let’s join the dots ... The most significant fact that we do know about the horse’s intestinal tract and Microbiota is that “The microbiome appears to be profoundly altered in certain disease states and It is ascertained that a better understanding of these alterations may offer hope for novel preventive and therapeutic measures DOI: 10.1017/S1466252312000035 · Source: PubMed Herbs and Epigenetics You may have heard about Epigenetics – the idea that our genes are not fixed, and that certain genes can be switched on to health, whilst other genes that make us susceptible to disease can be switched off. A study at Thailand University shows how herbs alter genes and enzymes – see this study https://www.hindawi.com/ journals/ecam/2011/816714/ for very interesting reading.