IVSA Journals - Fall 2015 | Page 32

FLUTD EFFICACY OF TWO COMMERCIALLY AVAILABLE, LOW-MAGNESIUM, URINE ACIDIFYING DRY FOODS FOR THE DISSOLUTION OF STRUVITE UROLITHS IN CATS Lulich JP, Kruger JM, MacLeay JM, et al. J Am Vet Med Assoc. 2013; 243(8):1147-1153. KEY POINTS: • First randomised, controlled clinical trial to show rapid dissolution of struvite uroliths in cats using dry therapeutic foods with a sodium content ≤ 0.41% (dry matter basis) • Nutritional management dissolved struvite uroliths in as little as 1 week (mean of 13 days for Hill’s™ Prescription Diet™ s/d™ Feline food, and 27 days for Hill’s™ Prescription Diet™ c/d™ Multicare Feline food) • Dissolution of struvite uroliths in cats using these therapeutic dry foods has been proposed as the primary modality of treatment at the most recent ACVIM A YEAR-LONG PROSPECTIVE, RANDOMIZED, DOUBLE-MASKED STUDY OF NUTRITION ON FELINE IDIOPATHIC CYSTITIS Kruger JM, Lulich JP, Merrills J, et al. J Am Vet Med Assoc. 2015; In press. KEY POINTS: • Compared with a control food, consistently feeding a dietetic urinary food (Hill’s™ Prescription Diet™ c/d™ Multicare) was associated with an 89% reduction in recurrent episodes of feline idiopathic cystitis (FIC) signs during a 12-month study • This is the first study to definitively show that foods of different nutritional profiles impact the expression of acute episodes of FIC signs in cats Clinical Evidence Review For Parent Products of Hill’s™ Prescription Diet™ Metabolic+Urinary Feline and Hill’s™ Prescription Diet™ Metabolic+Mobility Canine GENERAL BACKGROUND Forty percent of dogs with osteoarthritis (OA) are obese1. The biomechanical stress of excess weight is thought to be a primary contributor to the pathogenesis and progression of OA. In addition to the biomechanical stress, the constant low-grade inflammation associated with obesity may play a role in the development and progression of OA 2,3. Weight loss has been shown to improve the signs of OA in dogs4-13. Omega-3 fatty acids from fish oil provide clinical benefit by helping control inflammation and by reducing the expression and activity of cartilage proteoglycan-degrading enzymes14. In cats, being overweight or obese has been identified as a risk factor for feline lower urinary tract disease (FLUTD)15-17. While 14.5% of • Hill’s™ Prescription Diet™ Metabolic+Mobility has the nutritional attributes of Hill’s™ Prescription Diet™ Metabolic and Hill’s™ Prescription Diet™ j/d™ Canine: This nutrition has been clinically proven to improve mobility in as little as 21 days in dogs with osteoarthritis AND reduce body weight by 13% in 60 days. • Hill’s™ Prescription Diet™ Metabolic+Urinary has the nutritional attributes of Hill’s™ Prescription Diet™ Metabolic and Hill’s™ Prescription Diet™ c/d™ Multicare Feline: This nutrition has been clinically proven to dissolve struvite uroliths in cats in as little as 7 days (average 27 days), reduce the recurrence of FIC signs by 89% AND reduce body weight by 11% in 60 days. WEIGHT LOSS A REDUCED CALORIE, HIGH-FIBER FOOD WITH ADDED COCONUT OIL, L-CARNITINE, LYSINE, AND LEUCINE INCREASES BASAL METABOLIC RATE IN OVERWEIGHT AND OBESE DOGS Jewell D, Floerchinger A, Jackson M, et al. J Vet Intern Med. 2014; 28(3):1087-1088: (NM-9). KEY POINTS: • Obese dogs lost 1.4% body weight per week during first four months • Compared to the start of the study, after four months of maintenance feeding, lean body mass increased 2.6% XXXXXXXXXXXXXXXXXXXX ™ Trademarks owned by Hill’s Pet Nutrition, Inc. ©2015 Hill’s™ Prescription Diet™ Metabolic+Mobility has the nutritional attributes of Hill’s™ Prescription Diet™ Metabolic and Hill’s™ Prescription Diet™ j/d™ Canine. Hill’s™ Prescription Diet™ Metabolic+Urinary has the nutritional attributes of Hill’s™ Prescription Diet™ Metabolic and Hill’s™ Prescription Diet™ c/d™ Multicare Feline. Hill’s Evidence-Based Clinical Nutrition™ Summary 1. Banfield State of Health Report, 2012. 2. E  isele I, Wood IS, German AJ, et al. Adipokine gene expression in dog adipose tissues and dog white adipocytes differentiated in primary culture. Horm Metab Res 2005;37:474-481. 3. T  rayhurn P, Wood IS. Adipokines: inflammation and the pleiotropic role of white adipose tissue. Br J Nutr 2004;92:347-355. 4. M  oreau M, Troncy E, Bichot S, et al. Influence of changes in body weight on peak vertical force in osteoarthritic dogs: a possible bias in study outcome. Vet Surg 2010;39:43-47. 5. S  mith GK, Mayhew PD, Kapatkin AS, et al. Evaluation of risk factors for degenerative joint disease associated with hip dysplasia in German Shepherd Dogs, Golden Retrievers, Labrador Retrievers, and Rottweilers. J Am Vet Med Assoc 2001;219:1719-1724. 6. Huck JL, Biery DN, Lawler DF, et al. A longitudinal study of the influence of lifetime food restriction on development of osteoarthritis in the canine elbow. Vet Surg 2009;38:192-198. 7. R  unge JJ, Biery DN, Lawler DF, et al. The effects of lifetime food restriction on the development of osteoarthritis in the canine shoulder. Vet Surg 2008;37:102-107 8. S  mith GK, Paster ER, Powers MY, et al. Lifelong diet restriction and radiographic evidence of osteoarthritis of the hip joint in dogs. J Am Vet Med Assoc 2006;229:690-693. 9. Kealy RD, Lawler DF, Ballam JM, et al. Evaluation of the effect of limited food overweight/obese cats have signs of lower urinary tract disease, only 1% to 3% of the total population display signs of FLUTD. Foods formulated with increased levels of Omega-3 fatty acids from fish oil, antioxidants, and specific targets for minerals and urinary pH have been shown to reduce signs of FLUTD. Cats would bene