IVSA Journals - Fall 2015 | Page 32
FLUTD
EFFICACY OF TWO COMMERCIALLY AVAILABLE, LOW-MAGNESIUM, URINE
ACIDIFYING DRY FOODS FOR THE DISSOLUTION OF STRUVITE UROLITHS IN CATS
Lulich JP, Kruger JM, MacLeay JM, et al. J Am Vet Med Assoc. 2013; 243(8):1147-1153.
KEY POINTS:
• First randomised, controlled clinical trial to show
rapid dissolution of struvite uroliths in cats using
dry therapeutic foods with a sodium content
≤ 0.41% (dry matter basis)
• Nutritional management dissolved struvite
uroliths in as little as 1 week (mean of 13 days for
Hill’s™ Prescription Diet™ s/d™ Feline food, and 27
days for Hill’s™ Prescription Diet™ c/d™ Multicare
Feline food)
• Dissolution of struvite uroliths in cats using these
therapeutic dry foods has been proposed as the
primary modality of treatment at the most recent
ACVIM
A YEAR-LONG PROSPECTIVE, RANDOMIZED, DOUBLE-MASKED STUDY OF
NUTRITION ON FELINE IDIOPATHIC CYSTITIS
Kruger JM, Lulich JP, Merrills J, et al. J Am Vet Med Assoc. 2015; In press.
KEY POINTS:
• Compared with a control food, consistently
feeding a dietetic urinary food (Hill’s™
Prescription Diet™ c/d™ Multicare) was associated
with an 89% reduction in recurrent episodes of
feline idiopathic cystitis (FIC) signs during
a 12-month study
• This is the first study to definitively show that
foods of different nutritional profiles impact the
expression of acute episodes of FIC signs in cats
Clinical Evidence Review
For Parent Products of Hill’s™ Prescription Diet™ Metabolic+Urinary
Feline and Hill’s™ Prescription Diet™ Metabolic+Mobility Canine
GENERAL BACKGROUND
Forty percent of dogs with osteoarthritis (OA)
are obese1. The biomechanical stress of excess
weight is thought to be a primary contributor
to the pathogenesis and progression of OA.
In addition to the biomechanical stress, the
constant low-grade inflammation associated
with obesity may play a role in the development
and progression of OA 2,3.
Weight loss has been shown to improve
the signs of OA in dogs4-13. Omega-3 fatty
acids from fish oil provide clinical benefit by
helping control inflammation and by reducing
the expression and activity of cartilage
proteoglycan-degrading enzymes14.
In cats, being overweight or obese has been
identified as a risk factor for feline lower urinary
tract disease (FLUTD)15-17. While 14.5% of
• Hill’s™ Prescription Diet™ Metabolic+Mobility
has the nutritional attributes of Hill’s™
Prescription Diet™ Metabolic and Hill’s™
Prescription Diet™ j/d™ Canine:
This nutrition has been clinically proven to
improve mobility in as little as 21 days in dogs
with osteoarthritis AND reduce body weight by
13% in 60 days.
• Hill’s™ Prescription Diet™ Metabolic+Urinary
has the nutritional attributes of Hill’s™
Prescription Diet™ Metabolic and Hill’s™
Prescription Diet™ c/d™ Multicare Feline:
This nutrition has been clinically proven
to dissolve struvite uroliths in cats in as
little as 7 days (average 27 days), reduce
the recurrence of FIC signs by 89% AND
reduce body weight by 11% in 60 days.
WEIGHT LOSS
A REDUCED CALORIE, HIGH-FIBER FOOD WITH ADDED COCONUT OIL,
L-CARNITINE, LYSINE, AND LEUCINE INCREASES BASAL METABOLIC RATE
IN OVERWEIGHT AND OBESE DOGS
Jewell D, Floerchinger A, Jackson M, et al. J Vet Intern Med. 2014; 28(3):1087-1088: (NM-9).
KEY POINTS:
• Obese dogs lost 1.4% body weight per week during
first four months
• Compared to the start of the study, after four
months of maintenance feeding, lean body mass
increased 2.6%
XXXXXXXXXXXXXXXXXXXX
™ Trademarks owned by Hill’s Pet Nutrition, Inc. ©2015
Hill’s™ Prescription Diet™ Metabolic+Mobility has the
nutritional attributes of Hill’s™ Prescription Diet™
Metabolic and Hill’s™ Prescription Diet™ j/d™
Canine. Hill’s™ Prescription Diet™ Metabolic+Urinary
has the nutritional attributes of Hill’s™
Prescription Diet™ Metabolic and Hill’s™
Prescription Diet™ c/d™ Multicare Feline.
Hill’s Evidence-Based Clinical Nutrition™
Summary
1. Banfield State of Health Report, 2012.
2. E
isele I, Wood IS, German AJ, et al. Adipokine gene expression in dog adipose
tissues and dog white adipocytes differentiated in primary culture. Horm Metab
Res 2005;37:474-481.
3. T
rayhurn P, Wood IS. Adipokines: inflammation and the pleiotropic role of white
adipose tissue. Br J Nutr 2004;92:347-355.
4. M
oreau M, Troncy E, Bichot S, et al. Influence of changes in body weight on peak
vertical force in osteoarthritic dogs: a possible bias in study outcome. Vet Surg
2010;39:43-47.
5. S
mith GK, Mayhew PD, Kapatkin AS, et al. Evaluation of risk factors for
degenerative joint disease associated with hip dysplasia in German Shepherd
Dogs, Golden Retrievers, Labrador Retrievers, and Rottweilers. J Am Vet Med
Assoc 2001;219:1719-1724.
6. Huck JL, Biery DN, Lawler DF, et al. A longitudinal study of the influence of lifetime
food restriction on development of osteoarthritis in the canine elbow. Vet Surg
2009;38:192-198.
7. R
unge JJ, Biery DN, Lawler DF, et al. The effects of lifetime food restriction on the
development of osteoarthritis in the canine shoulder. Vet Surg 2008;37:102-107
8. S
mith GK, Paster ER, Powers MY, et al. Lifelong diet restriction and radiographic
evidence of osteoarthritis of the hip joint in dogs. J Am Vet Med Assoc
2006;229:690-693.
9. Kealy RD, Lawler DF, Ballam JM, et al. Evaluation of the effect of limited food
overweight/obese cats have signs of lower
urinary tract disease, only 1% to 3% of the total
population display signs of FLUTD. Foods
formulated with increased levels of Omega-3
fatty acids from fish oil, antioxidants, and
specific targets for minerals and urinary pH have
been shown to reduce signs of FLUTD. Cats
would bene