Ispectrum Magazine Ispectrum Magazine #06 | Page 46

that the optimally functioning iPump is the engine of quality sleep and recovery physiology, and therefore of nocturnal fat metabolism. Reduced consumption of refined sugars and carbohydrates, combined with honey taken prior to sleep every night, after an early evening meal, may constitute the single most significant and cost effective contribution to public health and learning in several generations. (c). Mike McInnes Mike McInnes is a retired Scottish pharmacist with a special interest in cerebral energy metabolism and its modern impairments. Mike, who lives in Edinburgh, has written The Honey Diet – a popular book on weight control that introduces the public to the glial cell and to chronic cerebral glucose deprivation as the driving force of obesity, via suppression of the cerebral glucose pump (iPump), and to sleep deprivation as a cofactor in weight gain. The Honey Diet is published by Hodder and Stoughton, Imprint of Hachette. January 2nd 2014. REFERENCES Aiello LC, Wheeler P. The Expensive Tissue Hypothesis: causation is posited as from obesity/type 2 diabetes to The Brain and the Digestive System in Human and Primate cognitive impairment – the reverse of the true sequence Evolution. Current Anthropology, Vol.36, No 2(Apr.,1995), of events in modern sugar driven suppression of the cere- pp. 199-221 bral glucose pump: http://www.iom.edu/~/media/Files/ Baker LD, Cross DJ, Minoshima S, Belongia D, Watson Activity%20Files/Children/NeuroEffectsChildren/Convit. GS, Craft S. pdf Insulin resistance and Alzheimer’s-like reductions in regional cerebral glucose metabolism for Denton M. University of Otago, New Zealand Excellent cognitively normal adults with prediabetes or early type 2 description of the colossal metabolic rate and energy diabetes. Arch Neurol. 2011 Jan;68(1):51-7. demand of the retina – 3 times that of the cerebral Bass J, Turek FW. Sleepless in America: A Pathway to cortex: http://www.arn.org/docs/odesign/od192/invert- Obesity and the Metabolic Syndrome? Arch Intern Med/ edretina192.htm Vol 165, Jan 10, 2005. “...The mammalian photoreceptor is capable of generat- Bellisle F. Infrequently the Mediterranean Diet. asked questions about ing electrical response to a single photon of light -- the Public Health Nutr. 2009 minimal bundle of light energy. This remarkable capacity Sep;12((A):1644-7 is dependent on a complex catalytic cascade consisting Benedict C, Kern W, Schmid SM, Schultes B, Born J, of a series of enzymes in the photoreceptor cell which Hallschmid M. Early morning rise in hypothalamic-pitu- massively amplifies the initial signal -- the absorption itary-adrenal activity: a role for maintaining the brain’s by a single rhodopsin molecule of a single photon. This energy balance. amplification process requires vast quantities of metabolic Psychneuroendocrinology. 2009 Apr; 34(3):455-62. energy and consequently the photoreceptor layer has one Convit A of the highest metabolic rates of any known tissue. The Excellent PP on impact of obesity and type 2 diabetes on brain structure and function. Again the oxygen consumption of the mammalian retina (per gram 45