features for the antigen. It is then possible
to isolate the antibodies
directly from the blood,
or even isolate particular antibody-producing blood cells from
the mixture extracted
from certain animals,
and initiate a complex
biotechnological procedure for the production
of an excess of a single
antibody. Antibodies
that are produced like
this are called “monoclonal”—they emanate
from one single cell line
and bind just one particular epitope.
Antibodies are very
small and, even under
a microscope, not readily visible, which is why
they are specially prepared for the diagnostics. They are coupled
with enzymes that produce visible colorants
or are marked with
fluorescing colorants.
There are two methods: The direct and the
indirect technique. The
latter works with an
added bridge that consists of another antibody (secondary antibody) that binds the
first one (primary antibody).
Antibodies help to distinguish tumor cells from each
other
One example is the antiIDH1 R132H monoclonal antibody clone H09
of DIANOVA GmbH, by
which different brain
tumors can be distinguished from each
other. Originally developed by the renowned
German
Cancer
Research Center, the
antibody labels glio36
mas, which account
for about 20 percent
of all brain tumors.
Differentiating gliomas
from other brain tumors
enables us to launch
a targeted treatment
and helps predict F