IN Peters Township December 2018/January 2019 | Page 58

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KIDNEY DISEASE
Autosomal Dominant
Polycystic
Kidney Dominant
Disease
Autosomal
Autosomal
Dominant
Christopher
Gisler, MD
Polycystic Kidney
Disease
Polycystic
Kidney
Disease
A
A A
utosomal Dominant Polycystic Kidney Disease is a genetic
disease affecting an estimated 1 in 400-1000 people. It is
the
4th leading
cause
of kidney Kidney
failure Disease
in the United
States.
utosomal
Dominant
Polycystic
is a genetic
utosomal
Dominant
Polycystic
Kidney
Disease
a genetic
ADPKD
causes cysts
to form
in 1 the
patient’s is
kidneys,
replacing
disease
affecting
an estimated
in 400-1000
people.
It is
disease
affecting
estimated
1 in
400-1000
people. States.
It is
healthy
kidney
tissue
with
fluid
filled
cysts.
Eventually,
these
the 4th
leading an
cause
of kidney
failure
in the
United
the all 4th
leading
cause
of causing
kidney
the United
States.
cysts replace
of the
kidney
tissue,
kidney
failure.
Over
half
of
the
ADPKD
causes
cysts
to form failure
in the in
patient’s
kidneys,
replacing
causes
cysts
to with
form
in the
kidneys,
replacing
people with ADPKD
ADPKD
will kidney
develop
failure
by fluid
the
age patient’s
of
50. These
patients
will
healthy
tissue
filled
cysts.
Eventually,
these
healthy
kidney
tissue
with causing
fluid filled
cysts.
Eventually,
these
require
dialysis
transplant.
cysts replace
all or of a the
kidney
tissue,
kidney
failure.
Over half
of the
cysts people
replace
all ADPKD
of the kidney
tissue, failure
causing
of the will
with
will develop
by kidney
the age failure.
of 50. Over
These half
patients
ADPKD
is a genetic
disease
and
is caused
of patients
the PKD1
or
people
with dialysis
ADPKD
develop
failure
by the by
age the
of mutation
50. These
will
require
or will
a kidney
transplant.
PKD2
gene. or It a is kidney
a dominant
mutation, so if you have it, your children will have a
require
dialysis
transplant.
50%
chance
of inheriting
the and
disease
from you.
ADPKD
is a genetic
disease
is caused
by the mutation of the PKD1 or
PKD2
It is disease
a dominant
so by
if you
it, your
will or have a
ADPKD
is a gene.
genetic
and mutation,
is caused
the have
mutation
of children
the PKD1
One
of
the
features
of ADPKD
is have
that for
years,
patients will
have
no a
50%
chance
inheriting
the disease
PKD2
gene.
It is concerning
a of dominant
mutation,
so from
if you you.
it, your
children
have
symptoms
at
all.
Even
routine
blood
tests
performed
by
their
doctors
may
not
50% chance of inheriting the disease from you.
show
As the
disease
it can patients
cause irreversible
One of the
the disease.
concerning
features
of silently
ADPKD progresses,
is that for years,
have no
to at
the all. kidneys.
Eventually
the
patient
see
noticeable
symptoms
Even
routine
tests
by to their
doctors
may
One damage
of the concerning
features
of blood
ADPKD
is performed
that will
for start
years,
patients
have
no not
symptoms,
like
high
blood
pressure,
blood
in
their
urine,
a
feeling
heaviness,
show
the
disease.
As
the
disease
silently
progresses,
it
can
cause
symptoms at all. Even routine blood tests performed by their doctors of irreversible
may
not
bloating or
in the abdomen
and/or
back, frequent
UTI’s
and
kidney stones.
to pain
the As
kidneys.
Eventually
the patient
will start
to see
noticeable
show damage
the disease.
the disease
silently
progresses,
it can
cause
irreversible
symptoms,
like high Eventually
blood pressure,
blood will
in their
a feeling
of heaviness,
damage
to the kidneys.
the patient
start urine,
to see
noticeable
bloating like
or pain
the abdomen
frequent
and of kidney
stones.
symptoms,
high in
blood
pressure, and/or
blood back,
in their
urine, a UTI’s
feeling
heaviness,
bloating or pain in the abdomen and/or back, frequent UTI’s and kidney stones.
Washington Health System Nephrology
offers comprehensive care of kidney disease,
Washington
Health electrolyte
System Nephrology
hypertension,
dialysis,
problems, and
offers comprehensive
care
of Nephrology
kidney disease,
Washington
Health System
associated
diseases.
hypertension,
dialysis, care
electrolyte
problems,
and
offers
comprehensive
of kidney
disease,
associated
diseases.
hypertension, dialysis,
electrolyte
problems, and
Providers
Office
associated diseases. Locations
Shirley J. Dopson, D.O.
Chris
Gisler, M.D.
Providers
Matt Magdic,
CRNP
Shirley
J. Dopson,
D.O.
Providers
Chris Gisler, M.D.
Shirley
J. Dopson,
D.O.
Matt
Magdic, CRNP
Chris Gisler, M.D.
Matt Magdic, CRNP
Washington, Cecil,
Burgettstown
and
Office
Locations
Waynesburg
Washington,
Cecil,
Office
Locations
Burgettstown
and
Washington,
Cecil,
Waynesburg
Burgettstown and
Waynesburg
To schedule an appointment please call [phone]
To schedule an appointment please call [phone]
56
724.942.0940 TO ADVERTISE
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To schedule an appointment please call [phone]
Christopher
Christopher Gisler,
Gisler, MD
MD
Though the disease mainly affects the kidneys, there are also related health
complications that can arise. ADPKD affects multiple other organ systems.
Cysts
on mainly
the kidneys.
condition
called
Valve
Prolapse
Though may
the occur
disease
affects A the
kidneys,
there Mitral
are also
related
health
Though
the disease
mainly
affects
the side
kidneys,
there
also
health
may
occur,
where
valve
in ADPKD
the left
of the
heart are
does
not related
function
complications
that the
can
arise.
affects
multiple
other
organ
systems.
complications
that
can
arise.
ADPKD
affects
multiple
other
organ
systems.
properly,
causing
back
leakage
of
blood
into
the
heart.
Brain
aneurysms
Cysts may occur on the kidneys. A condition called Mitral Valve Prolapse
Cysts
may in occur
kidneys.
condition
called
Mitral
Valve
Prolapse
develop
5-10%
of the
patients
ADPKD.
are
also
more
common.
may occur,
where on
the
valve
in with
the A left
side of Hernias
the
heart
does
not
function
may
occur, causing
where
the valve
in of the
side
of the
the heart.
heart
does
not function
Diverticulosis,
outpouchings
the
large
intestine
that can
become
infected,
properly,
back
leakage
of left
blood
into
Brain
aneurysms
properly,
leakage with
of blood
into Hernias
the heart.
aneurysms
are
also causing
common.
develop
in 5-10% back
of patients
ADPKD.
are Brain
also more
common.
develop
in 5-10%
of patients of with
Hernias
more infected,
common.
Diverticulosis,
outpouchings
the ADPKD.
large intestine
that are
can also
become
Previously,
treatment
for ADPKD
very
limited. that
ACE-inhibitors
(a infected,
class of
Diverticulosis,
outpouchings
of the were
large
intestine
can become
are also common.
blood
medications) were used to treat the disease. Patients were
are
also pressure
common.
encouraged
to drink a for
lot ADPKD
of water, were
avoid
caffeine
and
avoid nicotine.
Previously, treatment
very
limited.
ACE-inhibitors
(a Despite
class of
the
interventions,
the for
disease
tended
to very
progress.
blood
pressure
medications)
were
used
to treat
the ACE-inhibitors
disease. Patients (a were
Previously,
treatment
ADPKD
were
limited.
class of
encouraged
to medications)
drink a lot of water,
caffeine
and disease.
avoid nicotine.
Despite
blood
pressure
were avoid
used to
treat the
Patients
were
The
good news
is the
that
there
have
been
developments
in the treatment
the interventions,
tended
to recent
progress.
encouraged
to drink
a disease
lot
of water,
avoid
caffeine
and avoid nicotine.
Despite
of ADPKD.
A new
medication
was recently
approved to treat ADPKD that has
the
interventions,
the
disease tended
to progress.
been
shown
to slow
cyst
formation
and recent
preserve
healthy kidney
tissue.
The
The good
news
is that
there
have been
developments
in the
treatment
medication
requires
close
monitoring
by
a
neurologist.
of
ADPKD.
A
new
medication
was
recently
approved
to
treat
ADPKD
that
has
The good news is that there have been recent developments in the treatment
Though
ADPKD
is not
a curable
disease,
the outlook
can kidney
be good
for patients
been
shown
to
slow
cyst
formation
and
preserve
healthy
tissue.
The
of ADPKD. A new medication was recently approved to treat ADPKD that has
that
are on this
new medication,
Jynarque.
It can slow the progression of the
medication
close formation
monitoring
by preserve
a neurologist.
been
shown requires
to slow cyst
and
healthy kidney tissue. The
disease,
preserve is renal
function
and
avoid/prolong
the can
time
dialysis.
Though
ADPKD
not
a
curable
disease,
the
outlook
be to good
for patients
medication requires close monitoring by a neurologist.
that
are
on
this
new
medication,
Jynarque.
It
can
slow
the
progression
the
Though ADPKD is not a curable disease, the outlook can be good for of patients
Through
Washington
Health
System,
Dr. Dopson and
have to established
disease, preserve
renal
function
and avoid/prolong
the I time
dialysis. the
that are on this new medication, Jynarque. It can slow the progression of the
first ADPKD clinic in the area. We focus on the treatment of the disease as
disease,
preserve renal and
function and avoid/prolong
the time to of dialysis.
well
as pharmacologic
ADPKD the
and
Through
Washington Health nonpharmacological
System, Dr. Dopson management
and I have established
provide
information
for
patients
and
their
families.
first ADPKD clinic in the area. We focus on the treatment of the disease as
Through Washington Health System, Dr. Dopson and I have established the
well as pharmacologic and nonpharmacological management of ADPKD and
first ADPKD clinic in the area. We focus on the treatment of the disease as
provide information for patients and their families.
well as pharmacologic and nonpharmacological management of ADPKD and
provide
information
for patients
their
If you need
more information
or and
would
like families.
to make
an appointment, please call [phone].
If you need more information or would like to make
an appointment, please call [phone].
If you need more information or would like to make
Nephrology
Care call [phone].
an WHS
appointment,
please
Washington ...................................764 Locust Avenue
Cecil
Millers Run Road
WHS .........................................3415
Nephrology Care
Burgettstown
............................560
Steubenville
Pike
Washington ...................................764
Locust Avenue
Waynesburg
................................... 220
Greene
Plaza
Cecil
.........................................3415
Millers
Run
Road
WHS Nephrology Care
Burgettstown
............................560 Steubenville
Pike
Washington
...................................764
Locust Avenue
Waynesburg
................................... 220
Greene
Cecil
.........................................3415
Millers
Run Plaza
Road
[phone]
whs.org/nephrology
Burgettstown
............................560
Steubenville Pike
Waynesburg ................................... 220 Greene Plaza
[phone] whs.org/nephrology
[phone] whs.org/nephrology