HP Innovation Journal Issue 10: Fall 2018 - Page 61

landscape, including metabolic and immunological changes as well as the influence exerted by the microbiome. BIO-ENHANCING OUR MINDS AND BODIES » Our brains and bodies will also benefit from exploration in the biological realm, in the form of energy boosts, aging deterrents, productivity enhancers and disease controllers, to name a few. This segment is growing in investment and demand, with just the anti- aging therapies and services market forecast projected to reach $85.6 billion by 2022. 3 In traditional medicine, disease diagnostics and treatment strategies are developed for the population average and therefore do not always lead to improvement and may even lead to severe or even deadly side effects. With growing health concerns and an increasingly aging population, we can no longer rely on a one-size-fits-all health care approach. In the future, diagnostics and treatment approaches will be targeted according to individual biomarkers, creating personalized solutions for a better patient outcome. The field of theranostics is a significant area of focus in medicine. Theranostics describes the combination of precision diagnostics and therapeutics to provide custom-made, individualized therapies for various ailments and diseases. Breakthroughs in molecular biology have been vital in getting precision diagnostics off the ground. As an example, recent advances in next-generation DNA sequencing now allow routine genetic mutation identification to understand what drives specific diseases or how well a particular person would respond to treatment. While this approach is informative, genetic profiling alone does not capture the broader molecular Megatrends Center of the Future Multiomics profiling, which maps an individual’s genetic (genome), gene expression (transcriptome), protein (proteome), metabolic (metabolome) and gut microflora (microbiome) makeup, will be essential to accurately predict changes in health, monitor disease progression and inform of personalized drug therapies and dietary and lifestyle plans. In the therapeutics spectrum, regenerative medicine is generating a lot of excitement, as it promises to enhance functionality or repair what is broken or disabled. One approach to regenerative medicine is to harness the power of stem cells. While the therapeutic potential of embryo- derived stem cells has long been recognized, researchers have since made significant strides in demonstrating that adult stem cells can also be recovered from adult tissue and be differentiated into the desired cell line for therapy. This procedure bypasses the need for embr