Hooo-Hooo Volume 10, Nr 3 - Page 14

WildLife Group of the SAVA Reaction As hypotension and hypoxia are central in the pathogenesis of shock, cell degeneration and necrosis are most outspoken in those cells most susceptible to hypoxia such as neurons and cardiac myocytes as well as cells that do not get preferred circulation during shock (hepatocytes, renal tubular epithelium, adrenal cortical cells and gastrointestinal epithelium). Figure 2: Jaguar lung – shock lung with congestion, haemorrhage, oedema and diffuse microvesicular emphysema. Figure 3: Lion heart – paintbrush endocardial haemorrhage in the left ventricle involving the papillary musculature. Target tissues to be collected into 10% buffered formalin include • Lung: congestion, oedema, hemorrhages, alveolar epithelial necrosis, fluid flooding of alveoli with hyaline membrane formation. • Liver: diffuse (passive) congestion with centrilobular necrosis (hypoxic). • Kidney: acute renal tubular necrosis. • Intestine: congestion, oedema, haemorrhage and mucosal necrosis. • Heart: acute hyaline degeneration and necrosis with hypercontraction band formation. • Brain: cerebral oedema, neuronal degeneration and necrosis, cerebrocortical laminar necrosis. • Adrenal gland: haemorrhage at the corticomedullary junction. Tissue Residue Analysis Tissue residue analysis would be considered in instances where over-dosage is suspected. As most of the adverse drug reactions you are likely to encounter are dose independent, tissue residue analysis may not be of relevance. Target tissues for residue analysis include fresh liver, kidney, peri-renal fat and brain – transported on ice or frozen. Customised veterinary medicines to effectively address your patient’s requirements Service Centre: 0860 109 779 or pharmacist@v-tech.co.za 14 ISO 9001:2008 Accredited