Hooo-Hooo Volume 10, Nr 1 - Page 16

WildLife Group of the SAVA Vet Diagnostix Iron Storage Disease in a Golden Wildebeest Dr Rick Last – BVSc; M.Med.Vet (Pathology) Specialist Veterinary Pathologist Vetdiagnostix – Veterinary Pathology Services We received formalin-fixed tissues from a Golden Wildebeest cow that had died of complicated metabolic disease. The stand out histopathology was observed in the liver with moderate hepatocellular vacuolar degeneration (fatty change) and intracytoplasmic accumulation of granular brown iron-like pigment in many hepatocytes. (Figure 1) Pearls attaining for iron reveal strong positive blue staining of this pigment within hepatocytes. (Figure 2) Based on these findings a diagnosis of presumptive iron storage disease was made. Iron storage disease is an iron overload disorder associated with 16 progressive accumulation or iron, mainly in the form of ferritin and hemosiderin, which causes organ injury particularly to the liver, but can also be found in the heart, pancreas and kidney tubules. The distribution of iron pigment in iron storage disease is in hepatocytes, kupfer cells and portal macrophages. This differs from hemosiderosis associated with hemolysis where iron pigment accumulation occurs primarily in macrophages of the spleen and liver. Iron accumulation in hepatocytes is rarely seen with h [[