HeMe November issue | Page 24

MEDICAL SHORT NOTE No.1 Bile formation and it’s disturbances Functions of bile:1. Emulsification of dietary fat. 2. Elimination of bilirubin, excess cholesterol, xenobiotics and other waste products. Bile Formation:- Erythrocytes Hemoproteins Hepatic heme Heme Oxygenase Heme Heme Biliverdin Bile reductase Unconjugated bilirubin Spleen, Liver, Bone marrow Liver Glucouronic acid Unconjugated Conjugated Bilirubin Bilirubin UDP-UGT Bile Canaliculi