Fibromyalgia & Chronic Pain LIFE Mar/Apr 2013, Issue 8 - Page 15

many other conditions. People who have fibromyalgia not only have chronic pain, they are β€œsick.” The sickness response was first characterized in the mid1980s, but it wasn’t until the early 1990s 3,4 that it came to be recognized that pain facilitation is a potential sickness response 4,5,6 and is a natural consequence of exposure to stimuli that induce such a response. In further studies it has been shown that sicknessinduced pain facilitation is created by a well-defined immune-to-brain-to-spinal cord Α…Ρ‘݅䰁₯Έέ‘₯ Ρ‘”Ω•ΉΡΙ½΅•‘₯…°΅•‘Υ±±„΅ΡΌ΅ΝΑ₯Ή…°½ΙƒŠa±₯΅‹Šd½˜Ρ‘”Α…Ρ‘݅䁱•…‘́ѼΡ‘”Ι•±•…Ν”½˜Ή•ΥΙ½ΡΙ…ΉΝ΅₯ΡΡ•ΙΜ½Ή•ΥΙ½΅½‘Υ±…Ρ½Ίё…Ё…Ρ₯Ω…Ρ”ΝΑ₯Ή…°½Ι±₯„…Ή•Ή‘…Ή”Α…₯ΈΈΘΈ]…Ρ­₯ΉΟŠdέ½Ι¬₯ٕ́„Α±…ΥΝ₯‰±”Ρ‘•½ΙδΙ•…Ι‘₯ΉœΡ‘”½ΉΉ•Ρ₯½Έ‰•Ρέ••ΈΡ‘”₯΅΅ΥΉ”ΝεΝΡ•΄…ΉΡ‘”•ΉΡΙ…°Ή•ΙΩ½ΎΝεΝΡ•΄₯ΈΙ•±…Ρ₯½ΉΝ‘₯ΐΡΌΑ…₯ΈΈΈ•α…΅Α±”½˜Ρ‘•Ν”½ΉΉ•Ρ₯½ΉΜ₯́΅Υ±Ρ₯Α±”Ν±•Ι½Ν₯Μ°έ‘₯ ₯́…Έ…ΥΡ½₯΅΅ΥΉ”‘₯Ν½Ι‘•ΘΈ5L₯́„‘₯Ν•…Ν”Ρ‘…Ё₯ΉΩ½±Ω•Μ…Έ₯΅΅ΥΉ”ΝεΝΡ•΄…ΡΡ…¬……₯ΉΝЁё”•ΉΡΙ…°Ή•ΙΩ½ΎΝεΝΡ•΄€‘‰Ι…₯Έ°ΝΑ₯Ή…°½Ι°…Ή½ΑΡ₯ŒΉ•ΙΩ•Μ€Έ́Α…ΙЁ½˜Ρ‘”₯΅΅ΥΉ”…ΡΡ…¬½ΈΡ‘”•ΉΡΙ…°Ή•ΙΩ½ΎΝεΝΡ•΄°΅ε•±₯Έ€‘Ρ‘”™…ΡΡδΝΥ‰ΝΡ…Ή”Ρ‘…ЁΝΥΙΙ½ΥΉ‘́…ΉΑΙ½Ρ•Ρ́ё”Ή•ΙΩ”™₯‰•Ί₯ΈΡ‘”•ΉΡΙ…°Ή•ΙΩ½ΎΝεΝΡ•΄€₯́‘…΅…•°…́ݕ±°…́ё”Ή•ΙΩ”™₯‰•Ίё•΅Ν•±Ω•ΜΈQ‘”‘…΅…•΅ε•±₯Έ™½Ι΅ΜΝ…ȁΡ₯ΝΝΥ”€‘͍±•Ι½Ν₯Μ€°έ‘₯ ₯ٕ́ё”‘₯Ν•…Ν”₯Ρ́Ή…΅”Έ]‘•Έ…ΉδΑ…ΙЁ½˜Ρ‘”΅ε•±₯ΈΝ‘•…Ρ ½ΘΉ•ΙΩ”™₯‰•Θ₯Μ()‘…΅…•½Θ‘•ΝΡɽ啐°Ή•ΙΩ”₯΅Αձ͕́ΡΙ…Ω•±₯ΉœΡΌ…Ή™Ι½΄Ρ‘”‰Ι…₯Έ…ΉΝΑ₯Ή…°½Ι…Ι”‘₯ΝΡ½ΙΡ•½Θ₯ΉΡ•ΙΙΥΑΡ•°ΑΙ½‘Ս₯ΉœΡ‘”Ω…Ι₯•Ρ䁽˜Νε΅ΑΡ½΅ΜΡ‘…Ё…Έ½ΥΘΈ±Ρ‘½Υ ™₯‰Ι½΅ε…±₯„‘½•ΜΉ½ΠΝ‘½ά•Ω₯‘•Ή”½˜Ρ‘₯́ΡεΑ”½˜Ή•ΙΩ”‘…΅…”°™5I$₯΅…₯ΉœΝΡΥ‘₯•Μ‘…Ω”Ν‘½έΈ‘…Ή•Μ₯ΈΡ‘”‰Ι…₯Έ₯ΈΙ•…Ρ₯½ΈΡΌΑ…₯Έ₯ΈΑ•½Α±”έ₯Ρ ™₯‰Ι½΅ε…±₯„½΅Α…Ι•ΡΌ‘•…±Ρ‘䁍½ΉΡΙ½±Μ€άΈ=Ρ‘•Θ₯΅…₯ΉœΝΡΥ‘₯•Μ‘…Ω”Ν‘½έΈ„±…¬½˜„‘½Α…΅₯Ή”Ι•ΝΑ½ΉΝ”₯ΈΡ‘”‰Ι…₯ΈΡΌΑ…₯Έ₯Έ™₯‰Ι½΅ε…±₯„Α…Ρ₯•ΉΡ́½΅Α…Ι•ΡΌ‘•…±Ρ‘䁍½ΉΡΙ½°Α…ΙΡ₯₯Α…ΉΡ̀ก½Α…΅₯Ή”₯́ɕ±•…Ν•₯ΈΡ‘”‰Ι…₯ΈΡΌ‘•±ΐ‘½έΈ΅Ι•Υ±…Ρ”Α…₯Έμέ₯Ρ‘½ΥЁё₯́ɕΝΑ½ΉΝ”°Α…₯Έ₯ΉΡ•ΉΝ₯™₯•ΜΈ 䁑₯͍½Ω•Ι₯Ήœ…Έ…ΥΡ½₯΅΅ΥΉ”‘₯…Ή½ΝΡ₯Œ‰±½½Ρ•ΝЁ™½Θ™₯‰Ι½΅ε…±₯„°Α•Ι‘…ΆΘΈ₯±±₯́‘…́₯Ω•ΈΡ‘”έ½Ι±Ρ‘”™₯ΙΝЁΝΡ•ΐΡ½έ…ɐ„‰•Ρѕȁ͍₯•ΉΡ₯™₯ŒΥΉ‘•ΙΝΡ…Ή‘₯Ήœ½˜Ρ‘₯́‘Ι½Ή₯ŒΑ…₯Έ₯±±Ή•ΝΜΈ •…ΥΝ”½˜‘₯́ݽɬ°™ΥΡΥΙ”™₯‰Ι½΅ε…±₯„ΝΡΥ‘₯•Μέ₯±°‰”‘•Ν₯Ή•₯Έ‘₯™™•Ι•ΉΠέ…εΜ°έ‘₯ Ν‘½Υ±‘•±ΐΥΉ½Ω•ΘΉ•άΡΙ•…Ρ΅•ΉΡ́…ΉΑ•Ι‘…Άё”•±ΥΝ₯Ω”…ΥΝ”½˜™₯‰Ι½΅ε…±₯„ΈΘΈ]…Ρ­₯ΉΟŠdΥ±Ρ₯΅…Ρ”½…°₯́ѼΥΝ”Α…₯ΈΙ•Ν•…ɍ ‘₯͍½Ω•Ι₯•Μ₯ΉΩ½±Ω₯ΉœεΡ½­₯Ή•Μ°±₯„•±±Μ°…Ή₯ΉΡ•Ι±•Υ­₯ΉΜ€‘…΅½Ήœ½Ρ‘•Θ΅½±•Υ±…ȁ΅•ΝΝ•Ή•ΙΜ€ΡΌ‘•Ω•±½ΐΉ•άΡΙ•…Ρ΅•ΉΡ́™½Θ‘Ι½Ή₯ŒΑ…₯ΈΈA•Ι‘…Ά‘•Θέ½Ι¬…ΉΡ‘”Ι•Ν•…ɍ ΝΡΥ‘₯•Μ½˜½Ρ‘•Ίέ₯±°‰”•Ή‘…Ή•‰δΘΈ₯±±₯ϊd‘₯͍½Ω•Ι䰁…ΉΑ•½Α±”έ₯Ρ ™₯‰Ι½΅ε…±₯„έ₯±°‰”Ρ‘”‰•Ή•™…Ρ½Ί½˜Ή•άΝ₯•ΉΡ₯™₯Œ‰Ι•…­Ρ‘ɽ՝‘ΜΈ()II9 Lθ€ΔΈ •‘΄°…Ω½΄%4°₯±±₯Μ° L°•Π…°ΈUΉ₯ΕΥ”₯΅΅ΥΉ½±½₯ŒΑ…Ρѕɹ́₯Έ™₯‰Ι½΅ε…±₯„Έ 5  ±₯ΈA…Ρ‘½°€ΘΐΔΘμ€ΔΘθΘΤΈ€ΘΈ]…Ρ­₯ΉΜ°1H°5…₯•ΘMΈ%΅΅ΥΉ”Ι•Υ±…Ρ₯½Έ½˜•ΉΡΙ…°Ή•ΙΩ½ΎΝεΝΡ•΄™ΥΉΡ₯½ΉΜ聙ɽ΄Ν₯­Ή•Ν́ɕΝΑ½ΉΝ•ΜΡΌΑ…Ρ‘½±½₯…°Α…₯ΈΈ(%ΉΡ•ΙΈ5•€ΘΐΐΤμ€ΘΤάθΔΜδ΄ΤΤΈ€ΜΈQ…送°…ΉΡι•ΘH° Ι•ΝΡ…Ή€°1”5½…°4Έ%ΉΡ•Ι±Υ­₯Έ΄Δ₯Ή‘Ս•Μ½Ή‘₯Ρ₯½ΉΡ…ΝΡ”…Ω•ΙΝ₯½Έ₯ΈΙ…ΡΜ聄Α½ΝΝ₯‰±”•αΑ±…Ή…Ρ₯½Έ™½Θ₯Ρ́Α₯ΡΥ₯Ρ…Ιδ΅…‘Ι•Ή…°ΝΡ₯΅Υ±…Ρ₯Ήœ…Ρ₯Ω₯Ρ丁 Ι…₯ΈI•Μ€Δδΰΰμ€ΠάΜθ€ΜΨδ΄άΔΈ€ΠΈ5…₯•ΘM°]₯•Ιэ±…¬@°5…ΙΡ₯Έ°]…Ρ­₯ΉΜ1HΈ%ΉΡ•Ι±Υ­₯Έ΄Δ΅•‘₯…ѕ́ё”‰•‘…Ω₯½Ι…°‘εΑ•Ι…±•Ν₯„ΑΙ½‘Ս•‰δ±₯Ρ‘₯Υ΄‘±½Ι₯‘”…Ή•Ή‘½Ρ½α₯ΈΈ Ι…₯ΈI•Μ€ΔδδΜμ€ΨΘΜθ€ΜΘΔ΄ΠΈ€ΤΈ5…₯•ΘM°]₯•ΙΡ•±…¬@°]…Ρ­₯ΉΜ1HΈΉ‘½•Ή½ΎΑ…₯Έ™…₯±₯…Ρ½ΙδΝεΝΡ•΅Μ聅ΉΡ€΅…Ή…±•Ν₯„…Ή‘εΑ•Ι…±•Ν₯„Έ΄A…₯ΈM½Œ(€ΔδδΘμ€Δθ€ΔδΔ΄ΰΈ€ΨΈ]₯•ΙΡ•±…¬@°M΅₯Ρ -@°ΥΙΉ•Ν́$°•Π…°ΈΥΡ”…Ή½Ή‘₯Ρ₯½Ή•‘εΑ•Ι…±•Ν₯ŒΙ•ΝΑ½ΉΝ•ΜΡΌ₯±±Ή•ΝΜΈA…₯Έ€ΔδδΠμ€ΤΨθ€ΘΘά΄ΜΠΈ€άΈΙ…•±δI °A•Ρι­”°]½±˜)4° ±…Υ܁(ΈΥΉΡ₯½Ή…°΅…Ή•Ρ₯ŒΙ•Ν½Ή…Ή”₯΅…₯Ήœ•Ω₯‘•Ή”½˜…՝΅•ΉΡ•Α…₯ΈΑΙ½•ΝΝ₯Ήœ₯Έ™₯‰Ι½΅ε…±₯„ΈΙΡ‘Ι₯Ρ₯́I‘•Υ΄€ΘΐΐΘμ€ΠΨθ€ΔΜΜΜ΄ΠΜΈ€ΰΈ]½½A°M‘έ•₯Ή‘…ɑЁ@°)…••Θ°•Π…°Έ₯‰Ι½΅ε…±₯„Α…Ρ₯•ΉΡ́͑½ά…Έ…‰Ή½Ι΅…°‘½Α…΅₯Ή”Ι•ΝΑ½ΉΝ”ΡΌΑ…₯ΈΈΥȁ(9•Υɽ͍€€Θΐΐάμ€ΘΤθ€ΜΤάΨ΄ΰΘΈ()5…Θ½ΑΘ€ΘΐΔΜ()₯‰Ι½΅ε…±₯„€˜ ‘Ι½Ή₯ŒA…₯Έ()1₯™”((ΔΤ((0