EQUINE | Abstracts
EQUINE | Abstracts
days . This represented 6.3 % of horses that underwent laparotomy during the study period ( n = 1531 ). Relaparotomy was most frequently undertaken based on signs of persistent post-operative colic ( 76 %; n = 73 ). Shortterm survival for horses undergoing relaparotomy due to persistent colic was 53 %, incisional dehiscence 50 %, post-operative reflux 37 %, haemoperitoneum 17 % and septic peritonitis 0 %. Median survival was 6 days for all horses undergoing relaparotomy and 778 days for those that recovered following anaesthesia . Nonsurvival was associated with increased packed cell volume at 24 h following initial laparotomy ( hazard ratio [ HR ] 1.06 , 95 % confidence interval [ CI ] 1.04-1.10 , P = 0.009 ), peritonitis as a reason for undertaking relaparotomy ( HR 4.41 , 95 % CI 1.43-13.6 , P = 0.01 ) and adhesions found at relaparotomy ( HR 1.77 , 95 % CI 1.03-3.04 , P = 0.04 ). Increased likelihood of survival was associated with colic signs being the reason for performing relaparotomy ( HR 0.48 , 95 % CI 0.26-0.88 , P = 0.02 ) and small intestinal distension found at relaparotomy ( HR 0.53 , 95 % CI 0.29-0.96 , P = 0.04 ).
CONCLUSIONS : This study has provided information about survival rates and risk factors for survival in horses undergoing relaparotomy that can assist clinicians and owners when determining whether to perform relaparotomy and in predicting the likely surgical outcome .
The effects of dose and diet on the pharmacodynamics of omeprazole in the horse .
Sykes BW , et al . Equine Vet J . 2016 .
Abstract
BACKGROUND : Conflicting data are presented in the current literature regarding the efficacy of omeprazole for suppressing gastric acidity in the horse .
OBJECTIVES : The objective of this study was to investigate the duration of intraday acid suppression achieved with two doses of omeprazole under two different dietary conditions .
STUDY DESIGN : A four-way crossover design .
METHODS : Six adult Thoroughbred horses instrumented with percutaneous gastrotomy tubes were used . Intragastric pH was measured for continuous 23 h periods ( 08.00-07.00 h ) for six consecutive days ( Days 0-5 ). Baseline data was recorded on Day 0 and omeprazole administered on Days 1-5 . Two doses ( 1 mg / kg and 4 mg / kg bwt per os once a day ) and two diets ( a high grain / low fibre [ HG / LF ] and ad libitum hay [ HAY )] diet ) were studied . Data for the percent (%) time pH was above 4 (% tpH > 4 ) and median intraday pH was reported for two measurement locations and analysed using generalised estimating equations .
RESULTS : An effect of both diet and dose was evident with mean % tpH > 4 and the mean of the median intraday pHs typically higher at the higher ( 4 mg / kg bwt ) dose and in HG / LF diet . The overall efficacy of omeprazole in raising intragastric pH was good under the HG / LF conditions but relatively poor in the HAY diet . A cumulative effect of dosing , not previously reported in the horse , was observed .
CONCLUSIONS : The overall efficacy of omeprazole in raising ventral gastric pH was less than previously reported . Both dose and diet may play a role in the efficacy of omeprazole in the horse . Therefore , the use of singular dosing recommendations that encompass all horse types and management conditions may not be appropriate and dosing recommendations that take into account the diet of the horse may be advantageous .
• Volume 19 no 1 • February 2017 • 39