Equine Health Update EHU Vol 20 Issue 03 - Page 25

Equine Disease Quarterly | EQUINE the pathology of IBH and the fact that IL-5 drives eosinophil activity, a novel and allergen-independent vaccine has been evaluated that targets IL-5 and limits eosinophil recruitment to the affected skin. This is one of the few equine studies to investigate whether a vaccine can induce autoantibodies to cytokine IL-5 and result in clinical efficacy for IBH. This immunotherapeutic approach may be the new generation for treating chronic immune diseases, and may signal that new therapies are on the horizon for horses suffering from IBH. CONTACT: Amanda A. Adams, PhD, Amanda.adams@uky.edu, (859) 218-1097, Maxwell H. Gluck Equine Research Center, Univer- sity of Kentucky, Lexington, KY First Quarter, 2018 The International Collating Centre, Newmarket, United Kingdom, and other sources reported the following equine disease outbreaks. The Republic of South Africa (RSA) reported an expected seasonal increase in cases of African Horse Sickness. A total of 88 cases were recorded in eight of the nine provinces. No cases occurred in the Western Cape Province, including the Disease Controlled Area. The UK and the USA reported outbreaks of equine influenza. Two cases in recently imported non- vaccinated horses were recorded in the UK. The disease can be considered endemic in the USA in which it was confirmed in three states, with multiple outbreaks in one of the states. France, Germany, Ireland, and the USA reported multiple outbreaks of strangles. The number of outbreaks included 21 in France, two in Germany, numerous cases in Ireland, and 65 outbreaks in 22 states in the USA, 10 involving multiple cases of the disease. Equine herpesvirus 1 (EHV-1) infection was recorded in France, Germany, Ireland, Japan, RSA, Switzerland, the UK, and the USA. Infection associated with fever was reported by France (two outbreaks), Ireland (seven outbreaks), and Switzerland (one outbreak of combined EHV-1 and equine herpesvirus 4 infection). Respiratory disease was diagnosed in Germany (25 cases), the UK (eight outbreaks, majority in non- vaccinated, non-Thoroughbred horses), and the USA (widespread in various states). Cases of EHV-1 abortion were recorded in France (eight outbreaks, three involving multiple cases), Germany (four cases), Japan (single cases on 13 premises, all but four in vaccinated mares), the UK (five outbreaks involving vaccinated or non-vaccinated Thoroughbred and non- Thoroughbred mares), and the USA (two cases). EHV-1 associated neurologic disease was reported from France (one case), RSA (two cases on same premises), Switzerland (one case), the UK (a single case on two premises), and the USA (23 outbreaks involving 27 horses and multiple states). EHV-4 infection was recorded by France (four outbreaks) and Switzerland (two cases). France (10 outbreaks) and Germany (four cases) reported occurrences of EHV-4 related respiratory disease. Also, France confirmed one case of EHV-4 abortion. The USA recorded multiple cases of EHV-2/5 infection in several states, some associated with clinical evidence of respiratory disease. Equine infectious anemia was confirmed by Canada (three cases, one of which was clinical and died), France (one clinical case), and the USA (one case). • Volume 20 Issue 3 | October 2018 • 25