Equine Health Update EHU Vol 20 Issue 03 - Page 24

EQUINE | Equine Disease Quarterly Equine Disease Quarterly – July 2018 COMMENTARY Immunotherapies on the Horizon for Insect Bite Hypersensitivity? The season is upon us when approximately 10 percent of horses worldwide are faced with one of the most frustrating skin diseases in the equine industry, insect bite hypersensitivity (IBH), more commonly known as “sweet itch” or “summer eczema.” IBH is an allergic, recurrent, seasonal dermatitis caused when the immune system overacts or becomes ”hypersensitive” to allergens in the saliva primarily of biting midges (Culicoides) and other biting insects. Dr. Susan White in her article provides an overview of current diagnostic and management practices to combat signs of IBH. Although there is no cure for IBH, there is ongoing research to assess immunotherapies as future treatment options for horses suffering with IBH. While IBH has a multifactorial cause, it is acknowledged that the immune system plays a role in its development. Hypersensitivity reactions are classified into four types, and IBH is a combination of Type I and Type IV. Type I hypersensitivity reactions develop when antigen specific allergens bind to IgE and cross-link receptors on mast cells, basophils and also involve eosinophils. These cells release vasoactive amines, such as histamine, that 24 affect blood vessel size and leakage and produce inflammatory cytokines and other mediators, which result in inflammation and pruritus. Type IV reactions, often referred to as delayed-type hypersensitivity reactions, involve cell-mediated responses particularly of activated Th-2 lymphocytes which produce IL-5 cytokine and large numbers of eosinophils, both contribute to the clinical manifestations of IBH. Immunotherapy treatment is based on a century-old concept that the immune system can be desensitized to specific allergens that trigger hypersensitivity reactions. Allergen immunotherapy (AIT) involves inoculation with gradually increasing doses of an allergen to which the individual is allergic. The incremental increases in exposure to the allergen cause the immune system to become less sensitive to the substance, which reduces the allergy signs when the substance is encountered in the future. Data are conflicting as to whether or not traditional AIT therapies are successful in treating IBH. Research is now exploring whether IBH can be prevented by vaccination with recombinant Culicoides antigens versus whole antigen preparations to more successfully modulate the immune response, in particular, IgE response. Another interesting area under current investigation is oral immunotherapy, whereby transgenic barely expressing allergens are administered orally to prevent hypersensitivity to Culicoides. Finally, given the important role of eosinophils in • Equine Health Update •