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African Horse Sickness | EQUINE Immunohistochemical demonstration of African horse sickness viral antigen in formalin-fixed equine tissues. Veterinary pathology 1997;34:568-574. 11. Wohlsein P, Pohlenz JF, Salt JS, et al. Immunohistochemical demonstration of African horse sickness viral antigen in tissues of experimentally infected equines. Archives of virology Supplementum 1998;14:57-65. 12. Gomez-Villamandos JC, Sanchez C, Carrasco L, et al. Pathogenesis of African horse sickness: ultrastructural study of the capillaries in experimental infection. Journal of comparative pathology 1999;121:101-116. 13. Laegreid WW, Stone-Marschat M, Skowronek A, et al. Infection of endothelial cells by African Horse Sickness viruses. In: Walton TE, Osburn BI, eds. Bluetongue, African Horse Sickness, and Telated Orbiviruses. Boca Raton, Florida: CRC Press; 1992b:807-814. 14. Burrage TG, Laegreid WW. African horsesickness: pathogenesis and immunity. Comparative immunology, microbiology and infectious diseases 1994;17:275-285. 15. Brown CC, Meyer RF, Grubman MJ. Presence of African horse sickness virus in equine tissues, as determined by in situ hybridization. Veterinary pathology 1994;31:689-694. 16. Laegreid WW, Burrage TG, Stone-Marschat M, et al. Electron microscopic evidence for endothelial infection by African horsesickness virus. Veterinary pathology 1992;29:554-556. 17. Newsholme SJ. A morphological study of the lesions of African horsesickness. The Onderstepoort journal of veterinary research 1983;50:7-24. 18. Carrasco L, Sanchez C, Gomez-Villamandos JC, et al. The role of pulmonary intravascular macrophages in the pathogenesis of African horse sickness. Journal of comparative pathology 1999;121:25-38. 19. Chay S, Woods WE, Rowse K, et al. The pharmacology of furosemide in the horse. V. Pharmacokinetics and blood levels of furosemide after intravenous administration. Drug metabolism and disposition: the biological fate of chemicals 1983;11:226-231. 20. Johansson AM , Gardner SY, Levine JF, et al. Pharmacokinetics and pharmacodynamics of furosemide after oral administration to horses. Journal of veterinary internal medicine 2004;18:739-743. 21. Ettinger SJ, Benitz AM, Ericsson GF, et al. Effects of enalapril maleate on survival of dogs with naturally acquired heart failure. The Long-Term Investigation of Veterinary Enalapril (LIVE) Study Group. Journal of the American Veterinary Medical Association 1998;213:1573-1577. 22. Funck-Brentano C, van Veldhuisen DJ, van de Ven LL, et al. Influence of order and type of drug (bisoprolol vs. enalapril) on outcome and adverse events in patients with chronic heart failure: a post hoc analysis of the CIBIS-III trial. European journal of heart failure 2011;13:765-772. 23. Afonso T, Giguere S, Rapoport G, et al. Pharmacodynamic evaluation of 4 angiotensin-converting enzyme inhibitors in healthy adult horses. Journal of veterinary internal medicine 2013;27:1185- 1192. 24. Afonso T, Giguere S, Brown SA, et al. Preliminary investigation of orally administered benazepril in horses with left-sided valvular regurgitation. Equine veterinary journal 2017. 25. Brumbaugh GW, Thomas WP, Enos LR, et al. A pharmacokinetic study of digoxin in the horse. Journal of veterinary pharmacology and therapeutics 1983;6:163-172. 26. Button C, Gross DR, Johnston JT, et al. Digoxin pharmacokinetics, bioavailability, efficacy, and dosage regimens in the horse. Am J Vet Res 1980;41:1388-1395. 27. Sweeney RW, Reef VB, Reimer JM. Pharmacokinetics of digoxin administered to horses with congestive heart failure. Am J Vet Res 1993;54:1108-1111. 28. Boyle KL, Leech E. A review of the pharmacology and clinical uses of pimobendan. Journal of veterinary emergency and critical care (San Antonio, Tex : 2001) 2012;22:398-408. 29. Afonso T, Giguere S, Rapoport G, et al. Cardiovascular effects of pimobendan in healthy mature horses. Equine veterinary journal 2016;48:352-356. 30. Nath LC, Anderson GA, Hinchcliff KW, et al. Serum cardiac troponin I concentrations in horses with cardiac disease. Australian veterinary journal 2012;90:351-357. 31. Schwarzwald CC, Hardy J, Buccellato M. High cardiac troponin I serum concentration in a horse with multiform ventricular tachycardia and myocardial necrosis. Journal of veterinary internal medicine 2003;17:364-368. 32. Hewetson M, Shaik T. Myocardial dysfunction in horses with AHS – should we be reconsidering our treatment strategy? In: South African Equine Veterinary Association congress, Western Cape Province, South Africa 2018;179. 33. Slack JA, McGuirk SM, Erb HN, et al. Biochemical markers of cardiac injury in normal, surviving septic, or nonsurviving septic neonatal foals. Journal of veterinary internal medicine 2005;19:577- 580. 34. Noszczyk-Nowak A. NT-pro-BNP and troponin I as predictors of mortality in dogs with heart failure. Polish journal of veterinary sciences 2011;14:551-556. 35. Yang HS, Hur M, Yi A, et al. Prognostic Role of High-sensitivity Cardiac Troponin I and Soluble Suppression of Tumorigenicity-2 in Surgical Intensive Care Unit Patients Undergoing Non-cardiac Surgery. Annals of laboratory medicine 2018;38:204-211. • Volume 20 Issue 2 | July 2018 • 53