Equine Health Update EHU Vol 20 Issue 02 - Page 42

EQUINE | SAEVA Procedures and Policies Green – first line Green – first line Yellow – alternative Yellow – alternative Yellow – alternative Red – clinically important to human Red – clinically important to human Doses and Routes of Red – clinically important to human medicine medicine medicine Administration +++ Effective +++ Effective +++ Effective of Common Antimicrobial Drugs administration of common antimicrobial drug Colours represent likely use: Colours represent likely use: Green – first line Green - first line Yellow – alternative Yellow - alternative Red – clinically important to human Red - clinically important to human medicine medicine +++ Effective +++ Effective Antibiotic use policy Clinically important drugs are used only if culture and sensitivity testing suggest they are the only effective option. order to comply with good antimicrobial stewardship Clinically important drugs are used only if culture and sensitivity Clinically important drugs are used only if culture and sensitivity testing suggest they are the only effective option. Clinically important drugs are used only if culture and sensitivity testing suggest they are the only effective option. rgely rests on a document produced by the New Zealand Veterinary Drug Dose per kg Route Dosing tion-it most closely resembles the South African situation. Drug Dose per kg Route Drug Dose per kg Route Dosing Dosing interval for us by Dr Pia Randleff-Rasmussen- Drakenstein Veterinary Clinic interval Sodium penicillin 22,000-44,000 iu* IV interval 6 hours* Drug Dose per kg Route Dosing S Spectrum Notes interval Spectrum Notes Spectrum Notes Sodium penicillin 22,000-44,000 iu* IV 6 hours* + 22,000-44,000 iu* IM 24 hours* + ++ + ++ Procaine penicillin Wide distribution, poor penetration Benthazine penicillin (LA) Fails to reach MIC - avoid Sodium penicillin 22,000-44,000 iu* Sodium penicillin 22,000-44,000 iu* IV IM 6 hours* 6 hours* ++ ++ + + + ++ ++ ++ Wide distribution, poor penetration Wide distribution, poor penetration into CNS, abscess sites or necrosis. Procaine penicillin 22,000-44,000 iu* IV 24 hours* ++ Ceftiofur 2mg IM 12 hours* + Core Principles 22,000-44,000 iu* Procaine penicillin IM 24 hours* ++ ++ into CNS, abscess sites or necrosis. Procaine penicillin 22,000-44,000 iu* IM 24 hours* ++ + + ++ into CNS, abscess sites or necrosis. Procaine penicillin at higher doses is Benthazine penicillin (LA) Fails to reach MIC - avoid IV Cefquinome* IV 12 hours* + Procaine penicillin at higher doses is Procaine penicillin at higher doses is Benthazine penicillin (LA) above MIC at SID. 0.5-1mg Benthazine penicillin (LA) Fails to reach MIC - avoid Fails to reach MIC - avoid Oxytetracycline 5mg IV 12 hours* + f the impacts of antimicrobial use on human and animal health is made by all above MIC at SID. Ceftiofur 2mg IM 12 hours* +++ ++ ++ above MIC at SID. Clinically important 10mg Doxycycline* PO 12 hours* + Trimethoprim / 15-24mg IV 8-12 hours* + or administering antimicrobial agents. Ceftiofur 2mg IM +++ ++ Ceftiofur 2mg IM IV 12 hours* 12 hours* +++ ++ ++ ++ Clinically important Clinically important Higher dose for foals/ neonates 30mg PO 12 hours* Sulphadiazine onditions that could require antimicrobial therapy is a key focus of veterinary IV IV IV Higher dose for foals/ neonates Cefquinome* 0.5-1mg 12 hours* +++ ++ ++ Higher dose for foals/ neonates Clinically important Cefquinome* 0.5-1mg IV Cefquinome* 0.5-1mg IV IV 12 hours* 12 hours* +++ ++ ++ ++ ++ + Clinically important Clinically important Oxytetracycline 5mg 12 hours* +++ ++ ++ NB also Ehrlichia, richetsia and Gentamicin 6.6mg IV 24 hours + Oxytetracycline 5mg IV Oxytetracycline 5mg IV PO 12 hours* 12 hours* ++ ++ ++ ++ ++ + + + NB also Ehrlichia, richetsia and NB also Ehrlichia, richetsia and anaplasma antimicrobial agents only as required to maintain their health and welfare. Doxycycline* 10mg 12 hours* ++ Doxycycline* 10mg PO anaplasma Streptomycin 20mg IM 24 hours + Doxycycline* 10mg PO 12 hours* ++ ++ ++ ++ ++ + + - anaplasma Trimethoprim / 15-24mg IV 12 hours* 8-12 hours* ++ Ineffective S equi equi. Oral ing the number of animals given antimicrobial agents are employed where this Rifampin* 5mg IM 24 hours + Trimethoprim / 15-24mg IV 8-12 hours* ++ ++ - Ineffective S equi equi. Oral Trimethoprim / 15-24mg IV 8-12 hours* ++ ++ - Ineffective S equi equi. Oral Sulphadiazine 30mg PO 12 hours* bioavailability reduced in the presence mise animal health or welfare. Azithromycin* 10mg PO 24 hours + Sulphadiazine 30mg PO 12 hours* bioavailability reduced in the presence Sulphadiazine 30mg PO 12 hours* bioavailability reduced in the presence of food. bial agents are used, dose rates and regimens are designed to improve efficacy Clarithromycin 7.5mg PO 12 hours + of food. of food. Do no use IV form with detomidine. Enrofloxacin 5.5mg IV + 24 hours tment. 7.5mg PO Do no use IV form with detomidine. Gentamicin 6.6mg IV 24 hours + +++ - Do no use IV form with detomidine. Note dose in the neonate should be Marbofloxacin 2mg IV + 24 hours ents considered more important in human medicine are not used as first line Gentamicin 6.6mg IV 24 hours + + +++ Note dose in the neonate should be 3-3.5mg PO Gentamicin 6.6mg IV 24 hours +++ - - Note do