EQUINE
|
SAEVA
Procedures
and Policies
Green – first line
Green – first line
Yellow – alternative
Yellow – alternative
Yellow – alternative
Red – clinically important to human
Red – clinically important to human
Doses
and Routes of
Red – clinically important to human
medicine
medicine
medicine
Administration
+++ Effective
+++ Effective
+++ Effective
of Common
Antimicrobial Drugs
administration of common antimicrobial drug
Colours represent likely use:
Colours
represent likely use:
Green – first line
Green
- first line
Yellow – alternative
Yellow
- alternative
Red – clinically important to human
Red
- clinically important to human
medicine
medicine
+++ Effective
+++ Effective
Antibiotic use policy
Clinically important drugs are used only if culture and sensitivity testing suggest they are the only effective option.
order to comply with good antimicrobial stewardship
Clinically important drugs are used only if culture and sensitivity
Clinically important drugs are used only if culture and sensitivity testing suggest they are the only effective option.
Clinically important drugs are used only if culture and sensitivity testing suggest they are the only effective option.
rgely rests on a document produced by the New Zealand Veterinary
Drug
Dose per kg
Route Dosing
tion-it most closely resembles the South African situation.
Drug
Dose per kg
Route
Drug
Dose per kg
Route Dosing
Dosing
interval
for us by Dr Pia Randleff-Rasmussen- Drakenstein Veterinary Clinic
interval
Sodium penicillin
22,000-44,000 iu* IV interval
6 hours*
Drug
Dose per kg
Route Dosing
S
Spectrum
Notes
interval
Spectrum
Notes
Spectrum
Notes
Sodium penicillin
22,000-44,000 iu* IV
6 hours*
+
22,000-44,000 iu* IM
24 hours*
+
++
+
++ Procaine penicillin
Wide distribution, poor penetration
Benthazine penicillin (LA)
Fails to reach MIC - avoid
Sodium penicillin
22,000-44,000 iu*
Sodium penicillin
22,000-44,000 iu*
IV IM 6 hours*
6 hours*
++ ++ + + + ++
++ ++ Wide distribution, poor penetration
Wide distribution, poor penetration
into CNS, abscess sites or necrosis.
Procaine penicillin
22,000-44,000 iu* IV
24 hours* ++
Ceftiofur
2mg
IM
12 hours*
+
Core Principles 22,000-44,000 iu*
Procaine penicillin
IM
24 hours*
++
++
into CNS, abscess sites or necrosis.
Procaine penicillin
22,000-44,000 iu*
IM
24 hours*
++ + +
++ into CNS, abscess sites or necrosis.
Procaine penicillin at higher doses is
Benthazine penicillin (LA)
Fails to reach MIC - avoid
IV
Cefquinome*
IV
12 hours*
+
Procaine penicillin at higher doses is
Procaine penicillin at higher doses is
Benthazine penicillin (LA)
above MIC at SID. 0.5-1mg
Benthazine penicillin (LA) Fails to reach MIC - avoid
Fails to reach MIC - avoid
Oxytetracycline
5mg
IV
12 hours*
+
f the impacts of antimicrobial use on human and animal health is made by all
above MIC at SID.
Ceftiofur
2mg
IM
12 hours*
+++ ++
++ above MIC at SID.
Clinically important 10mg
Doxycycline*
PO
12 hours*
+
Trimethoprim /
15-24mg
IV
8-12 hours*
+
or administering antimicrobial agents.
Ceftiofur
2mg
IM
+++
++
Ceftiofur
2mg
IM IV 12 hours*
12 hours*
+++ ++
++
++ Clinically important
Clinically important
Higher dose for foals/ neonates
30mg
PO
12 hours*
Sulphadiazine
onditions that could require antimicrobial therapy is a key focus of veterinary
IV
IV IV
Higher dose for foals/ neonates
Cefquinome*
0.5-1mg
12 hours*
+++ ++
++ Higher dose for foals/ neonates
Clinically important
Cefquinome*
0.5-1mg
IV
Cefquinome*
0.5-1mg
IV IV 12 hours*
12 hours*
+++
++ ++ ++
++ + Clinically important
Clinically important
Oxytetracycline
5mg
12 hours* +++
++ ++
NB also Ehrlichia, richetsia and
Gentamicin
6.6mg
IV
24 hours
+
Oxytetracycline
5mg
IV
Oxytetracycline
5mg
IV PO 12 hours*
12 hours*
++ ++ ++
++ ++ + + + NB also Ehrlichia, richetsia and
NB also Ehrlichia, richetsia and
anaplasma
antimicrobial agents only as required to maintain their health and welfare.
Doxycycline*
10mg
12 hours* ++
Doxycycline*
10mg
PO
anaplasma
Streptomycin
20mg
IM
24 hours
+
Doxycycline*
10mg
PO
12 hours*
++ ++ ++
++ ++ + + - anaplasma
Trimethoprim /
15-24mg
IV 12 hours*
8-12 hours* ++
Ineffective S equi equi. Oral
ing the number of animals given antimicrobial agents are employed where this
Rifampin*
5mg
IM
24 hours
+
Trimethoprim /
15-24mg
IV
8-12 hours*
++
++
-
Ineffective S equi equi. Oral
Trimethoprim /
15-24mg
IV
8-12 hours*
++
++
-
Ineffective S equi equi. Oral
Sulphadiazine
30mg
PO
12 hours*
bioavailability reduced in the presence
mise animal health or welfare.
Azithromycin*
10mg
PO
24 hours
+
Sulphadiazine
30mg
PO
12 hours*
bioavailability reduced in the presence
Sulphadiazine
30mg
PO
12 hours*
bioavailability reduced in the presence
of food.
bial agents are used, dose rates and regimens are designed to improve efficacy
Clarithromycin
7.5mg
PO
12 hours
+
of food.
of food.
Do no use IV form with detomidine.
Enrofloxacin
5.5mg
IV
+
24 hours
tment.
7.5mg
PO
Do no use IV form with detomidine.
Gentamicin
6.6mg
IV
24 hours
+
+++
- Do no use IV form with detomidine.
Note dose in the neonate should be
Marbofloxacin
2mg
IV
+
24 hours
ents considered more important in human medicine are not used as first line
Gentamicin
6.6mg
IV
24 hours
+ +
+++
Note dose in the neonate should be
3-3.5mg
PO
Gentamicin
6.6mg
IV
24 hours
+++ - -
Note do