Equine Health Update EHU Vol 19 Issue 4 - Page 18

EQUINE | Equine Disease Update An alternative but slower approach is to culture C. perfringens and confirm the presence of toxin genes (cpb for type C and netF for type A) by PCR. In terms of prevention, an autogenous bacterintoxoid vaccine has been used for mare immunization in Ken- tucky in an attempt to prevent type A C. perfringens enteritis in foals. This vaccine likely includes NetF toxin since mares immunized with the vaccine have antibodies to NetF. Hyperimmune plasma is com- mercially available for the prevention or treatment of necrotizing enteritis in foals caused by C. perfringens types A (including NetF), C, and D. Although the discovery of NetF has furthered our un- 18 derstanding of C. perfringens enterocolitis in foals, further work is required to fully understand how NetF- producing type A C. perfringens causes disease. Re- search studies are slowly chipping away at C. perfrin- gens enterocolitis, and the discovery of NetF has been another important step forward. Contact: Iman Mehdizadeh Gohari imehdiza@uoguelph.ca John F. Prescott prescott@uoguelph.ca (519) 824-4120 ext. 54716 Department of Pathobiology Ontario Veterinary College University of Guelph, Canada • Equine Health Update •