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Lucretia became one of the founders of the “Female Anti-Slavery Society” in 1833. Lucretia and husband James were both very devoted to the abolishment of slavery, but James always said that Lucretia was the one with more of a firm leadership for the movement. The more famous became, it seemed like the worse her growing case of dyspepsia or a mild discomfort in the upper abdomen, it occurs during or right after eating. Lucretia also attended the first ever Anti-Slavery Convention of American Women, which she proudly helped to organize. She made sure that her speeches were much “feminized” and were always focused on Anti-Slavery.