THE BE T
Multimedia Highlights
From the CardioSource WorldNews YouTube Channel | Scan the QR code to watch the full video
We Are Not Alone: Intestinal
Microbial Communities and the
Congested Gut in Heart Failure
W.H. Wilson Tang, MD: “There is a running joke
that we are 10% human and 90% microbes, so
there is really a huge amount of understanding
that we will need to relate what we see at the
bedside to this new information.”
Comprehensive Care of the Heart:
Realizing the Powerful Impact of
Changes in Diet and Lifestyle
Dean Ornish, MD: “I went back to the U.S.
Department of Agriculture database, where
they track what the entire population is actually
eating (not what they say they’re eating), which
they’ve been tracking in every decade since
1950. What I learned was that, although people
have been told to eat less fat, every decade
since 1950 we’re eating more fat, more sugar,
more calories and more meat. So not surprisingly, we’re fatter.”
Two Papers Look at TAVR vs. SAVR in
Intermediate-risk Patients
Vinod H. Thourani, MD: “For the first time,
we’re seeing a transcatheter valve technology
(the SAPIEN 3) being shown to be superior to
surgery in a propensity score analysis. I think we
need to redefine, or at least re-think in our minds
within the heart team: ‘Are w e now seeing a superior therapy in transcatheter valve therapies?’”
Thourani V, Kodali S, Makkar R, et al. Lancet.
2016;387:2218-25.
Tang W. JCHF. 2016;4:228-9.
Additional Important Outcomes
Improved with Biventricular Pacing:
More from BLOCK-HF
Inflammation in Heart Failure with
Preserved Ejection Fraction: Time to
Put Out the Fire?
DAPT Score for Risk Prediction
After PCI
Curtis A, et al. J Am Coll Cardiol.
2016;67(18):2148-57.
Gomberg-Maitland M, Shah SJ, Guazzi M.
JCHF. 2016;4:325-8.
Kereiakes D, Yeh R, Massaro J, et al. J Am Coll
Cardiol. 2016;67(21):2492-502.
Anne B. Curtis, MD: “The good news is that for
the clinical composite score, we found a significant benefit and improvement in patients with
biventricular pacing over right ventricular pacing
throughout the 2 years of follow-up.”
10
CardioSource WorldNews
Sanjiv Shah, MD: “We really need that translational science going back and forth. […] The [T-1
translation trial] concept is that basically, in animal
models, we often find discoveries, and then we
wait for a long time to translate that to humans. We
do Phase 1, 2 and 3 studies, but it can be several
years between discoveries in animal models and
translation to humans. What we’re saying is that
we should jump-start that process by doing a T-1
study. As soon as we find something in the animal
model, we should translate that to
the human, and do these detailed
mechanistic studies early on.”
Laura Mauri, MD: “The DAPT Score came out
of the recognition that clinical trials don’t tell us
everything just by themselves. The single result
of a clinical study is difficult for physicians to interpret. After we completed the DAPT Study, and
actually even before, we knew that there would
be a trade-off between preventing ischemic
events and increased bleeding.”
July 2016