the authors, increasing these studies
will help transform care and improve
outcomes for the growing population
of older patients with CVD.
Healthy Families
and Healthy Hearts
Rich MW, Chyun DA, Skolnick AH, et al.
J Am Coll Cardiol. 2016;doi:10.1016/j.
jacc.2016.03.004.
Family-based approaches, particularly
those targeting communication as
well as structural and environmental
conditions, are the most effective in
promoting cardiovascular health,
according to a state-of-the-art review
recently published in JACC.
Rates of incident CVD continue to
rise in the U.S., largely due to modifiable behavior. Habits learned during
childhood largely influence behaviors
Chronic Angina may
be holding him back
For patients limiting their activity due to
chronic angina, adding Ranexa® may help
In the CARISA Trial1
Ranexa 1000 mg BID,* when added to a beta-blocker
or calcium channel blocker,† was superior to those
treatments plus placebo at:
Increasing exercise duration (24 secs change vs placebo from
baseline at Week 12)
Increasing the time to onset of ischemia during exercise
testing at peak plasma concentrations (94 vs 59 secs)
Decreasing angina frequency (2.1 vs 3.3 avg/wk)
Decreasing nitroglycerin use (1.8 vs 3.1 avg doses/wk)
Learn how Ranexa may help your patients get back on track
www.RanexaHCP.com/CSWN
BID = twice daily
*Limit the dose of Ranexa to 500 mg BID when coadministered with diltiazem, verapamil, or other moderate
CYP3A inhibitors.
†
CARISA TRIAL DESIGN1: CARISA (Combination Assessment of Ranolazine In Stable Angina) was a doubleblind, randomized, placebo-controlled clinical trial of 823 patients with chronic angina who received Ranexa
750 mg BID (n = 272), Ranexa 1000 mg BID (n = 261), or placebo (n = 258) for 12 weeks (note, 750 mg is not
an approved dose). At the physician’s discretion, patients received either atenolol 50 mg, amlodipine 5 mg,
or diltiazem 180 mg once daily as required background antianginal therapy. Sublingual nitrates were used as
needed. Corresponding P-values < 0.05.
Please see following page for brief summary of
Full Prescribing Information.
Dosage and Administration
Begin treatment with 500 mg
twice daily and increase to the
maximum recommended dose
of 1000 mg twice daily, based on
clinical symptoms. Ranexa should
be swallowed whole; do not crush,
break or chew.
Limit the dose of Ranexa to 500